Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
Summary: Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422030691X |
| _version_ | 1819085634932834304 |
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| author | Ane Ruiz-de-Angulo Marc Bilbao-Asensio James Cronin Stephen J. Evans Martin J.D. Clift Jordi Llop Irene V.J. Feiner Rhiannon Beadman Kepa Zamacola Bascarán Juan C. Mareque-Rivas |
| author_facet | Ane Ruiz-de-Angulo Marc Bilbao-Asensio James Cronin Stephen J. Evans Martin J.D. Clift Jordi Llop Irene V.J. Feiner Rhiannon Beadman Kepa Zamacola Bascarán Juan C. Mareque-Rivas |
| author_sort | Ane Ruiz-de-Angulo |
| collection | DOAJ |
| description | Summary: Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy. |
| first_indexed | 2024-12-21T21:07:29Z |
| format | Article |
| id | doaj.art-a5826939d70947b2815106ea34cb9aab |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T21:07:29Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a5826939d70947b2815106ea34cb9aab2022-12-21T18:50:14ZengElsevieriScience2589-00422020-09-01239101499Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor FerroptosisAne Ruiz-de-Angulo0Marc Bilbao-Asensio1James Cronin2Stephen J. Evans3Martin J.D. Clift4Jordi Llop5Irene V.J. Feiner6Rhiannon Beadman7Kepa Zamacola Bascarán8Juan C. Mareque-Rivas9Chemical Immunology Laboratory, CIC BioGUNE, Building 801A, Derio 48160, Spain; Corresponding authorDepartment of Chemistry and Centre for NanoHealth, Swansea University, Singleton Park, Swansea SA2 8PP, UKSwansea University Medical School, Institute of Life Science, Singleton Park, Swansea SA2 8PP, UKSwansea University Medical School, Institute of Life Science, Singleton Park, Swansea SA2 8PP, UKSwansea University Medical School, Institute of Life Science, Singleton Park, Swansea SA2 8PP, UKRadiochemistry and Nuclear Imaging Laboratory, CIC BiomaGUNE, Paseo Miramón 182, San Sebastián 20014, SpainRadiochemistry and Nuclear Imaging Laboratory, CIC BiomaGUNE, Paseo Miramón 182, San Sebastián 20014, SpainSwansea University Medical School, Institute of Life Science, Singleton Park, Swansea SA2 8PP, UKRadiochemistry and Nuclear Imaging Laboratory, CIC BiomaGUNE, Paseo Miramón 182, San Sebastián 20014, SpainDepartment of Chemistry and Centre for NanoHealth, Swansea University, Singleton Park, Swansea SA2 8PP, UK; Corresponding authorSummary: Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy.http://www.sciencedirect.com/science/article/pii/S258900422030691XImmunologyBiomaterialsNanomaterialsCancerTherapy |
| spellingShingle | Ane Ruiz-de-Angulo Marc Bilbao-Asensio James Cronin Stephen J. Evans Martin J.D. Clift Jordi Llop Irene V.J. Feiner Rhiannon Beadman Kepa Zamacola Bascarán Juan C. Mareque-Rivas Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis iScience Immunology Biomaterials Nanomaterials Cancer Therapy |
| title | Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis |
| title_full | Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis |
| title_fullStr | Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis |
| title_full_unstemmed | Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis |
| title_short | Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis |
| title_sort | chemically programmed vaccines iron catalysis in nanoparticles enhances combination immunotherapy and immunotherapy promoted tumor ferroptosis |
| topic | Immunology Biomaterials Nanomaterials Cancer Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S258900422030691X |
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