Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma
Cuproptosis is a newly discovered type of cell death. The role and potential mechanism of Cuproptosis-related genes (CRGs) in the prognosis of cancer patients are not fully understood. In this study, we included two cohorts of clear cell renal cell carcinoma patients, TCGA and E-MTAB-1980. The TCGA...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7507 |
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| author | Tuanjie Guo Jian Zhang Zhihao Yuan Heting Tang Tao Wang Xiang Wang Siteng Chen |
| author_facet | Tuanjie Guo Jian Zhang Zhihao Yuan Heting Tang Tao Wang Xiang Wang Siteng Chen |
| author_sort | Tuanjie Guo |
| collection | DOAJ |
| description | Cuproptosis is a newly discovered type of cell death. The role and potential mechanism of Cuproptosis-related genes (CRGs) in the prognosis of cancer patients are not fully understood. In this study, we included two cohorts of clear cell renal cell carcinoma patients, TCGA and E-MTAB-1980. The TCGA cohort is used as a training set to construct a CRG signature using the LASSO-cox regression analysis, and E-MTAB-1980 is used as a cohort for verification. A total of eight genes (<i>FDX1</i>, <i>LIAS</i>, <i>LIPT1</i>, <i>DLAT</i>, <i>PDHA1</i>, <i>MTF1</i>, <i>GLS</i>, <i>CDKN2A</i>) were screened to construct a prognostic model in the TCGA cohort. There is a significant difference in OS (<i>p</i> < 0.0001) between the high and low cuproptosis score group, and a similar difference is also observed in the OS (<i>p</i> = 0.0054) of the E-MTAB-1980 cohort. The area under the ROC curves (AUC) were 0.87, 0.82, and 0.78 at 1, 3, and 5 years in the TCGA cohort, respectively. Finally, gene set enrichment analysis revealed that CRGs were associated with cell cycle and mitotic signaling pathways. |
| first_indexed | 2024-03-09T16:16:03Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:16:03Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a583a3c4ec31489097cee4f22d3ce1152023-11-24T15:46:49ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124750710.3390/jcm11247507Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell CarcinomaTuanjie Guo0Jian Zhang1Zhihao Yuan2Heting Tang3Tao Wang4Xiang Wang5Siteng Chen6Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaCuproptosis is a newly discovered type of cell death. The role and potential mechanism of Cuproptosis-related genes (CRGs) in the prognosis of cancer patients are not fully understood. In this study, we included two cohorts of clear cell renal cell carcinoma patients, TCGA and E-MTAB-1980. The TCGA cohort is used as a training set to construct a CRG signature using the LASSO-cox regression analysis, and E-MTAB-1980 is used as a cohort for verification. A total of eight genes (<i>FDX1</i>, <i>LIAS</i>, <i>LIPT1</i>, <i>DLAT</i>, <i>PDHA1</i>, <i>MTF1</i>, <i>GLS</i>, <i>CDKN2A</i>) were screened to construct a prognostic model in the TCGA cohort. There is a significant difference in OS (<i>p</i> < 0.0001) between the high and low cuproptosis score group, and a similar difference is also observed in the OS (<i>p</i> = 0.0054) of the E-MTAB-1980 cohort. The area under the ROC curves (AUC) were 0.87, 0.82, and 0.78 at 1, 3, and 5 years in the TCGA cohort, respectively. Finally, gene set enrichment analysis revealed that CRGs were associated with cell cycle and mitotic signaling pathways.https://www.mdpi.com/2077-0383/11/24/7507cuproptosisclear cell renal cell carcinomaprognosissignaturecell cycle |
| spellingShingle | Tuanjie Guo Jian Zhang Zhihao Yuan Heting Tang Tao Wang Xiang Wang Siteng Chen Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma Journal of Clinical Medicine cuproptosis clear cell renal cell carcinoma prognosis signature cell cycle |
| title | Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma |
| title_full | Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma |
| title_fullStr | Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma |
| title_full_unstemmed | Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma |
| title_short | Cuproptosis-Related Genes Are Associated with Cell Cycle and Serve as the Prognostic Signature for Clear Cell Renal Cell Carcinoma |
| title_sort | cuproptosis related genes are associated with cell cycle and serve as the prognostic signature for clear cell renal cell carcinoma |
| topic | cuproptosis clear cell renal cell carcinoma prognosis signature cell cycle |
| url | https://www.mdpi.com/2077-0383/11/24/7507 |
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