Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly
Polysaccharide coated nanoparticles represent a promising class of environmentally friendly latex to replace those stabilized by small toxic molecular surfactants. We report here an in situ formulation of free-surfactant core/shell nanoparticles latex consisting of dextran-based diblock amphiphilic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/23/4064 |
| _version_ | 1797507372973817856 |
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| author | Valeria Lizeth Romero Castro Brahim Nomeir Ana Andreea Arteni Malika Ouldali Jean-Luc Six Khalid Ferji |
| author_facet | Valeria Lizeth Romero Castro Brahim Nomeir Ana Andreea Arteni Malika Ouldali Jean-Luc Six Khalid Ferji |
| author_sort | Valeria Lizeth Romero Castro |
| collection | DOAJ |
| description | Polysaccharide coated nanoparticles represent a promising class of environmentally friendly latex to replace those stabilized by small toxic molecular surfactants. We report here an in situ formulation of free-surfactant core/shell nanoparticles latex consisting of dextran-based diblock amphiphilic copolymers. The synthesis of copolymers and the immediate latex formulation were performed directly in water using a photo-initiated reversible addition fragmentation chain transfer-mediated polymerization induced self-assembly strategy. A hydrophilic macromolecular chain transfer-bearing photosensitive thiocarbonylthio group (eDexCTA) was first prepared by a modification of the reducing chain end of dextran in two steps: (i) reductive amination by ethylenediamine in the presence of sodium cyanoborohydride, (ii) then introduction of CTA by amidation reaction. Latex nanoparticles were then formulated in situ by chain-extending eDexCTA using 2-hydroxypropyl methacrylate (HPMA) under 365 nm irradiation, leading to amphiphilic dextran-<i>b</i>-poly(2-hydroxypropyl methacrylate) diblock copolymers (DH<sub>X</sub>). Solid concentration (SC) and the average degree of polymerization -<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo> </mo><mover accent="true"><mrow><msub><mi>X</mi><mi>n</mi></msub></mrow><mo stretchy="true">ˉ</mo></mover></mrow></semantics></math></inline-formula>- of PHPMA block (<i>X</i>) were varied to investigate their impact on the size and the morphology of latex nanoparticles termed here SCDH<sub>X</sub>. Light scattering and transmission electron microscopy analysis revealed that SCDH<sub>X</sub> form exclusively spherical nano-objects. However, the size of nano-objects, ranging from 20 nm to 240 nm, increases according to PHPMA block length. |
| first_indexed | 2024-03-10T04:47:35Z |
| format | Article |
| id | doaj.art-a584e8d17b354d28afa4d7b2ffe3a16a |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T04:47:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-a584e8d17b354d28afa4d7b2ffe3a16a2023-11-23T02:52:20ZengMDPI AGPolymers2073-43602021-11-011323406410.3390/polym13234064Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-AssemblyValeria Lizeth Romero Castro0Brahim Nomeir1Ana Andreea Arteni2Malika Ouldali3Jean-Luc Six4Khalid Ferji5Université de Lorraine, CNRS, LCPM, 54000 Nancy, FranceUniversité de Lorraine, CNRS, LCPM, 54000 Nancy, FranceCryo-Electron Microscopy Facility, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198 Gif-sur-Yvette, FranceCryo-Electron Microscopy Facility, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198 Gif-sur-Yvette, FranceUniversité de Lorraine, CNRS, LCPM, 54000 Nancy, FranceUniversité de Lorraine, CNRS, LCPM, 54000 Nancy, FrancePolysaccharide coated nanoparticles represent a promising class of environmentally friendly latex to replace those stabilized by small toxic molecular surfactants. We report here an in situ formulation of free-surfactant core/shell nanoparticles latex consisting of dextran-based diblock amphiphilic copolymers. The synthesis of copolymers and the immediate latex formulation were performed directly in water using a photo-initiated reversible addition fragmentation chain transfer-mediated polymerization induced self-assembly strategy. A hydrophilic macromolecular chain transfer-bearing photosensitive thiocarbonylthio group (eDexCTA) was first prepared by a modification of the reducing chain end of dextran in two steps: (i) reductive amination by ethylenediamine in the presence of sodium cyanoborohydride, (ii) then introduction of CTA by amidation reaction. Latex nanoparticles were then formulated in situ by chain-extending eDexCTA using 2-hydroxypropyl methacrylate (HPMA) under 365 nm irradiation, leading to amphiphilic dextran-<i>b</i>-poly(2-hydroxypropyl methacrylate) diblock copolymers (DH<sub>X</sub>). Solid concentration (SC) and the average degree of polymerization -<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo> </mo><mover accent="true"><mrow><msub><mi>X</mi><mi>n</mi></msub></mrow><mo stretchy="true">ˉ</mo></mover></mrow></semantics></math></inline-formula>- of PHPMA block (<i>X</i>) were varied to investigate their impact on the size and the morphology of latex nanoparticles termed here SCDH<sub>X</sub>. Light scattering and transmission electron microscopy analysis revealed that SCDH<sub>X</sub> form exclusively spherical nano-objects. However, the size of nano-objects, ranging from 20 nm to 240 nm, increases according to PHPMA block length.https://www.mdpi.com/2073-4360/13/23/4064iniferterPISAphoto-RAFT polymerizationlatex nanoparticleemulsiondispersion |
| spellingShingle | Valeria Lizeth Romero Castro Brahim Nomeir Ana Andreea Arteni Malika Ouldali Jean-Luc Six Khalid Ferji Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly Polymers iniferter PISA photo-RAFT polymerization latex nanoparticle emulsion dispersion |
| title | Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly |
| title_full | Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly |
| title_fullStr | Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly |
| title_full_unstemmed | Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly |
| title_short | Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly |
| title_sort | dextran coated latex nanoparticles via photo raft mediated polymerization induced self assembly |
| topic | iniferter PISA photo-RAFT polymerization latex nanoparticle emulsion dispersion |
| url | https://www.mdpi.com/2073-4360/13/23/4064 |
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