Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients
Gaigai Bai,1,2 Yue Zhou,1,2 Qing Rong,1,2 Sijing Qiao,1,2 Hongluan Mao,1,2,* Peishu Liu1,2,* 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/development-of-nomogram-models-based-on-peripheral-blood-score-and-cli-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797861367910236160 |
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| author | Bai G Zhou Y Rong Q Qiao S Mao H Liu P |
| author_facet | Bai G Zhou Y Rong Q Qiao S Mao H Liu P |
| author_sort | Bai G |
| collection | DOAJ |
| description | Gaigai Bai,1,2 Yue Zhou,1,2 Qing Rong,1,2 Sijing Qiao,1,2 Hongluan Mao,1,2,* Peishu Liu1,2,* 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongluan Mao; Peishu Liu, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People’s Republic of China, Tel +86-18560081988 ; +86-18560082027, Email peishuliu@126.com; hongluanmao@126.comPurpose: Nutritional and inflammatory states are crucial in cancer development. The purpose of this study is to construct a scoring system grounded on peripheral blood parameters associated with nutrition and inflammation and explore its value in stage, overall survival (OS), and progression-free survival (PFS) prediction for epithelial ovarian cancer (EOC) patients.Patients and Methods: Four hundred and fifty-three EOC patients were retrospectively identified and their clinical data and relevant peripheral blood parameters were collected. The ratio of neutrophil to lymphocyte, lymphocyte to monocyte, fibrinogen to lymphocyte, total cholesterol to lymphocyte and albumin level were calculated and dichotomized. A scoring system named peripheral blood score (PBS) was constructed. Univariate and multivariate Logistic or Cox regression analyses were used to select independent factors; these factors were then used to develop nomogram models of advanced stage and OS, PFS, respectively. The internal validation and DCA analysis were performed to evaluate models.Results: Lower PBS indicated a better prognosis and higher PBS indicated inferior. High PBS is associated with advanced stage, high CA125, serous histological type, poor differentiation, and accompanied ascites. The logistic regression showed age, CA125, and PBS were independent factors for the FIGO III–IV stage. The nomogram models for advanced FIGO stage based on these factors showed good efficiency. FIGO stage, residual disease, and PBS were independent factors affecting OS and PFS, the nomogram models composed of these factors had good performance. DCA curves revealed the models augmented net benefits.Conclusion: PBS can be a noninvasive biomarker for EOC patients’ prognosis. The related nomogram models could be powerful, cost-effective tools to provide information of advanced stage, OS, and PFS for EOC patients.Keywords: inflammation, nutrition, ovarian cancer, predict model, peripheral blood |
| first_indexed | 2024-04-09T22:01:13Z |
| format | Article |
| id | doaj.art-a58676e1e4094b5cbbed4f21d79aa2d5 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-09T22:01:13Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-a58676e1e4094b5cbbed4f21d79aa2d52023-03-23T18:06:52ZengDove Medical PressJournal of Inflammation Research1178-70312023-03-01Volume 161227124182480Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer PatientsBai GZhou YRong QQiao SMao HLiu PGaigai Bai,1,2 Yue Zhou,1,2 Qing Rong,1,2 Sijing Qiao,1,2 Hongluan Mao,1,2,* Peishu Liu1,2,* 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongluan Mao; Peishu Liu, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People’s Republic of China, Tel +86-18560081988 ; +86-18560082027, Email peishuliu@126.com; hongluanmao@126.comPurpose: Nutritional and inflammatory states are crucial in cancer development. The purpose of this study is to construct a scoring system grounded on peripheral blood parameters associated with nutrition and inflammation and explore its value in stage, overall survival (OS), and progression-free survival (PFS) prediction for epithelial ovarian cancer (EOC) patients.Patients and Methods: Four hundred and fifty-three EOC patients were retrospectively identified and their clinical data and relevant peripheral blood parameters were collected. The ratio of neutrophil to lymphocyte, lymphocyte to monocyte, fibrinogen to lymphocyte, total cholesterol to lymphocyte and albumin level were calculated and dichotomized. A scoring system named peripheral blood score (PBS) was constructed. Univariate and multivariate Logistic or Cox regression analyses were used to select independent factors; these factors were then used to develop nomogram models of advanced stage and OS, PFS, respectively. The internal validation and DCA analysis were performed to evaluate models.Results: Lower PBS indicated a better prognosis and higher PBS indicated inferior. High PBS is associated with advanced stage, high CA125, serous histological type, poor differentiation, and accompanied ascites. The logistic regression showed age, CA125, and PBS were independent factors for the FIGO III–IV stage. The nomogram models for advanced FIGO stage based on these factors showed good efficiency. FIGO stage, residual disease, and PBS were independent factors affecting OS and PFS, the nomogram models composed of these factors had good performance. DCA curves revealed the models augmented net benefits.Conclusion: PBS can be a noninvasive biomarker for EOC patients’ prognosis. The related nomogram models could be powerful, cost-effective tools to provide information of advanced stage, OS, and PFS for EOC patients.Keywords: inflammation, nutrition, ovarian cancer, predict model, peripheral bloodhttps://www.dovepress.com/development-of-nomogram-models-based-on-peripheral-blood-score-and-cli-peer-reviewed-fulltext-article-JIRinflammationnutritionovarian cancerpredict modelperipheral blood |
| spellingShingle | Bai G Zhou Y Rong Q Qiao S Mao H Liu P Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients Journal of Inflammation Research inflammation nutrition ovarian cancer predict model peripheral blood |
| title | Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients |
| title_full | Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients |
| title_fullStr | Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients |
| title_full_unstemmed | Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients |
| title_short | Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients |
| title_sort | development of nomogram models based on peripheral blood score and clinicopathological parameters to predict preoperative advanced stage and prognosis for epithelial ovarian cancer patients |
| topic | inflammation nutrition ovarian cancer predict model peripheral blood |
| url | https://www.dovepress.com/development-of-nomogram-models-based-on-peripheral-blood-score-and-cli-peer-reviewed-fulltext-article-JIR |
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