Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy

Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy

Abstract Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N‐acetyltransferase 2 (NAT2) but the pharmacokinetics (PK) of INH in diff...

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Bibliographic Details
Main Authors:	Ogochukwu U. Amaeze, Nina Isoherranen
Format:	Article
Language:	English
Published:	Wiley 2023-11-01
Series:	Clinical and Translational Science
Online Access:	https://doi.org/10.1111/cts.13614

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