A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment
Myeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell population among immune cells within the tumour microenvironment (TME) that support cancer progression and resistance to therapy. During tumour progression, cancer cells modify their metabolism to sustain an increas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2700 |
| _version_ | 1827679912142569472 |
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| author | Francesca Hofer Gianna Di Sario Chiara Musiu Silvia Sartoris Francesco De Sanctis Stefano Ugel |
| author_facet | Francesca Hofer Gianna Di Sario Chiara Musiu Silvia Sartoris Francesco De Sanctis Stefano Ugel |
| author_sort | Francesca Hofer |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell population among immune cells within the tumour microenvironment (TME) that support cancer progression and resistance to therapy. During tumour progression, cancer cells modify their metabolism to sustain an increased energy demand to cope with uncontrolled cell proliferation and differentiation. This metabolic reprogramming of cancer establishes competition for nutrients between tumour cells and leukocytes and most importantly, among tumour-infiltrating immune cells. Thus, MDSCs that have emerged as one of the most decisive immune regulators of TME exhibit an increase in glycolysis and fatty acid metabolism and also an upregulation of enzymes that catabolise essential metabolites. This complex metabolic network is not only crucial for MDSC survival and accumulation in the TME but also for enhancing immunosuppressive functions toward immune effectors. In this review, we discuss recent progress in the field of MDSC-associated metabolic pathways that could facilitate therapeutic targeting of these cells during cancer progression. |
| first_indexed | 2024-03-10T06:39:44Z |
| format | Article |
| id | doaj.art-a589bc45fdd94af79f3581b327ce5332 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:44Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a589bc45fdd94af79f3581b327ce53322023-11-22T17:47:44ZengMDPI AGCells2073-44092021-10-011010270010.3390/cells10102700A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour MicroenvironmentFrancesca Hofer0Gianna Di Sario1Chiara Musiu2Silvia Sartoris3Francesco De Sanctis4Stefano Ugel5Immunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyImmunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyImmunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyImmunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyImmunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyImmunology Section, Department of Medicine, University of Verona, 37134 Verona, ItalyMyeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell population among immune cells within the tumour microenvironment (TME) that support cancer progression and resistance to therapy. During tumour progression, cancer cells modify their metabolism to sustain an increased energy demand to cope with uncontrolled cell proliferation and differentiation. This metabolic reprogramming of cancer establishes competition for nutrients between tumour cells and leukocytes and most importantly, among tumour-infiltrating immune cells. Thus, MDSCs that have emerged as one of the most decisive immune regulators of TME exhibit an increase in glycolysis and fatty acid metabolism and also an upregulation of enzymes that catabolise essential metabolites. This complex metabolic network is not only crucial for MDSC survival and accumulation in the TME but also for enhancing immunosuppressive functions toward immune effectors. In this review, we discuss recent progress in the field of MDSC-associated metabolic pathways that could facilitate therapeutic targeting of these cells during cancer progression.https://www.mdpi.com/2073-4409/10/10/2700myeloid-derived suppressor cells (MDSC)cancertumour-microenvironment (TME)inflammationimmunometabolism |
| spellingShingle | Francesca Hofer Gianna Di Sario Chiara Musiu Silvia Sartoris Francesco De Sanctis Stefano Ugel A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment Cells myeloid-derived suppressor cells (MDSC) cancer tumour-microenvironment (TME) inflammation immunometabolism |
| title | A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment |
| title_full | A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment |
| title_fullStr | A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment |
| title_full_unstemmed | A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment |
| title_short | A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment |
| title_sort | complex metabolic network confers immunosuppressive functions to myeloid derived suppressor cells mdscs within the tumour microenvironment |
| topic | myeloid-derived suppressor cells (MDSC) cancer tumour-microenvironment (TME) inflammation immunometabolism |
| url | https://www.mdpi.com/2073-4409/10/10/2700 |
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