A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment

A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment

Myeloid-derived suppressor cells (MDSCs) constitute a plastic and heterogeneous cell population among immune cells within the tumour microenvironment (TME) that support cancer progression and resistance to therapy. During tumour progression, cancer cells modify their metabolism to sustain an increas...

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Bibliographic Details
Main Authors: Francesca Hofer, Gianna Di Sario, Chiara Musiu, Silvia Sartoris, Francesco De Sanctis, Stefano Ugel
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
myeloid-derived suppressor cells (MDSC)
cancer
tumour-microenvironment (TME)
inflammation
immunometabolism
Online Access:https://www.mdpi.com/2073-4409/10/10/2700

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