Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries
Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative psychiatric outcomes may reflect the detrimental impact of substance abuse on...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301888 |
| _version_ | 1818579987678101504 |
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| author | Joseph Aloi Karina S. Blair Kathleen I. Crum Harma Meffert Stuart F. White Patrick M. Tyler Laura C. Thornton Alita M. Mobley Abraham D. Killanin Kathryn O. Adams Francesca Filbey Kayla Pope R. James R. Blair |
| author_facet | Joseph Aloi Karina S. Blair Kathleen I. Crum Harma Meffert Stuart F. White Patrick M. Tyler Laura C. Thornton Alita M. Mobley Abraham D. Killanin Kathryn O. Adams Francesca Filbey Kayla Pope R. James R. Blair |
| author_sort | Joseph Aloi |
| collection | DOAJ |
| description | Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative psychiatric outcomes may reflect the detrimental impact of substance abuse on neural systems mediating emotion processing and executive attention. However, work indicative of this has mostly been conducted either in animal models or adults with Alcohol and/or Cannabis Use Disorder (AUD/CUD). Little work has been conducted in adolescent patients. In this study, we used the Affective Stroop task to examine the relationship in 82 adolescents between AUD and/or CUD symptom severity and the functional integrity of neural systems mediating emotional processing and executive attention. We found that AUD symptom severity was positively related to amygdala responsiveness to emotional stimuli and negatively related to responsiveness within regions implicated in executive attention and response control (i.e., dorsolateral prefrontal cortex, anterior cingulate cortex, precuneus) as a function of task performance. In contrast, CUD symptom severity was unrelated to amygdala responsiveness but positively related to responsiveness within regions including precuneus, posterior cingulate cortex, and inferior parietal lobule as a function of task performance. These data suggest differential impacts of alcohol and cannabis abuse on the adolescent brain. Keywords: Adolescent, Alcohol Use Disorder, Amygdala, Cannabis Use Disorder, fMRI, Prefrontal cortex |
| first_indexed | 2024-12-16T07:10:26Z |
| format | Article |
| id | doaj.art-a58acb83d8294bb58aee67713c8249d3 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-16T07:10:26Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-a58acb83d8294bb58aee67713c8249d32022-12-21T22:39:55ZengElsevierNeuroImage: Clinical2213-15822018-01-0119782792Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitriesJoseph Aloi0Karina S. Blair1Kathleen I. Crum2Harma Meffert3Stuart F. White4Patrick M. Tyler5Laura C. Thornton6Alita M. Mobley7Abraham D. Killanin8Kathryn O. Adams9Francesca Filbey10Kayla Pope11R. James R. Blair12Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States; Corresponding author at: Center for Neurobehavioral Research, Boys Town National Research Hospital, 14100 Crawford Street, Boys Town, NE 68010, United States.Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for BrainHealth, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States; Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE, United States; Department of Psychiatry, Creighton University, Omaha, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesAlcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative psychiatric outcomes may reflect the detrimental impact of substance abuse on neural systems mediating emotion processing and executive attention. However, work indicative of this has mostly been conducted either in animal models or adults with Alcohol and/or Cannabis Use Disorder (AUD/CUD). Little work has been conducted in adolescent patients. In this study, we used the Affective Stroop task to examine the relationship in 82 adolescents between AUD and/or CUD symptom severity and the functional integrity of neural systems mediating emotional processing and executive attention. We found that AUD symptom severity was positively related to amygdala responsiveness to emotional stimuli and negatively related to responsiveness within regions implicated in executive attention and response control (i.e., dorsolateral prefrontal cortex, anterior cingulate cortex, precuneus) as a function of task performance. In contrast, CUD symptom severity was unrelated to amygdala responsiveness but positively related to responsiveness within regions including precuneus, posterior cingulate cortex, and inferior parietal lobule as a function of task performance. These data suggest differential impacts of alcohol and cannabis abuse on the adolescent brain. Keywords: Adolescent, Alcohol Use Disorder, Amygdala, Cannabis Use Disorder, fMRI, Prefrontal cortexhttp://www.sciencedirect.com/science/article/pii/S2213158218301888 |
| spellingShingle | Joseph Aloi Karina S. Blair Kathleen I. Crum Harma Meffert Stuart F. White Patrick M. Tyler Laura C. Thornton Alita M. Mobley Abraham D. Killanin Kathryn O. Adams Francesca Filbey Kayla Pope R. James R. Blair Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries NeuroImage: Clinical |
| title | Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries |
| title_full | Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries |
| title_fullStr | Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries |
| title_full_unstemmed | Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries |
| title_short | Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries |
| title_sort | adolescents show differential dysfunctions related to alcohol and cannabis use disorder severity in emotion and executive attention neuro circuitries |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301888 |
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