Acyclovir crystalluria: The utility of bedside urine routine microscopic examination
Acyclovir, an acyclic nucleoside, is commonly used for the treatment of viral infections. Acyclovir is well tolerated in children. However, severe nephrotoxicity has been shown to occur in some children. One of the mechanisms for acyclovir-induced nephrotoxicity is acyclovir-induced crystalluria. Pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Pediatric Critical Care |
| Subjects: | |
| Online Access: | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2020;volume=7;issue=5;spage=282;epage=284;aulast=Jain |
| _version_ | 1818315682279849984 |
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| author | Puneet Jain Ramachandran Rameshkumar Ponnarmeni Satheesh Subramanian Mahadevan |
| author_facet | Puneet Jain Ramachandran Rameshkumar Ponnarmeni Satheesh Subramanian Mahadevan |
| author_sort | Puneet Jain |
| collection | DOAJ |
| description | Acyclovir, an acyclic nucleoside, is commonly used for the treatment of viral infections. Acyclovir is well tolerated in children. However, severe nephrotoxicity has been shown to occur in some children. One of the mechanisms for acyclovir-induced nephrotoxicity is acyclovir-induced crystalluria. Prompt attention to urine microscopy examination can help avoid drug-induced nephrotoxicity. Here, we report a case of a seven-year-old febrile comatose child who received intravenous empirical acyclovir therapy and developed cloudy urine. Bedside urine microscopic examination shows fine-needle-shaped crystal. The urine was cleared within 12 h of stopping the acyclovir and adequate intravascular hydration. A child recovered without evidence of acute kidney injury. |
| first_indexed | 2024-12-13T09:09:25Z |
| format | Article |
| id | doaj.art-a58f68bfd026470aa0cb9c3036a50f38 |
| institution | Directory Open Access Journal |
| issn | 2349-6592 2455-7099 |
| language | English |
| last_indexed | 2024-12-13T09:09:25Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pediatric Critical Care |
| spelling | doaj.art-a58f68bfd026470aa0cb9c3036a50f382022-12-21T23:52:59ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992020-01-017528228410.4103/jpcc.jpcc_90_20Acyclovir crystalluria: The utility of bedside urine routine microscopic examinationPuneet JainRamachandran RameshkumarPonnarmeni SatheeshSubramanian MahadevanAcyclovir, an acyclic nucleoside, is commonly used for the treatment of viral infections. Acyclovir is well tolerated in children. However, severe nephrotoxicity has been shown to occur in some children. One of the mechanisms for acyclovir-induced nephrotoxicity is acyclovir-induced crystalluria. Prompt attention to urine microscopy examination can help avoid drug-induced nephrotoxicity. Here, we report a case of a seven-year-old febrile comatose child who received intravenous empirical acyclovir therapy and developed cloudy urine. Bedside urine microscopic examination shows fine-needle-shaped crystal. The urine was cleared within 12 h of stopping the acyclovir and adequate intravascular hydration. A child recovered without evidence of acute kidney injury.http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2020;volume=7;issue=5;spage=282;epage=284;aulast=Jainacyclovirchildrencomplicationscrystalluriamicroscopyurine examination |
| spellingShingle | Puneet Jain Ramachandran Rameshkumar Ponnarmeni Satheesh Subramanian Mahadevan Acyclovir crystalluria: The utility of bedside urine routine microscopic examination Journal of Pediatric Critical Care acyclovir children complications crystalluria microscopy urine examination |
| title | Acyclovir crystalluria: The utility of bedside urine routine microscopic examination |
| title_full | Acyclovir crystalluria: The utility of bedside urine routine microscopic examination |
| title_fullStr | Acyclovir crystalluria: The utility of bedside urine routine microscopic examination |
| title_full_unstemmed | Acyclovir crystalluria: The utility of bedside urine routine microscopic examination |
| title_short | Acyclovir crystalluria: The utility of bedside urine routine microscopic examination |
| title_sort | acyclovir crystalluria the utility of bedside urine routine microscopic examination |
| topic | acyclovir children complications crystalluria microscopy urine examination |
| url | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2020;volume=7;issue=5;spage=282;epage=284;aulast=Jain |
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