Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/10/10/668 |
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| author | Balázs Decsi Réka Krammer Kristóf Hegedűs Ferenc Ender Benjámin Gyarmati András Szilágyi Róbert Tőtős Gabriel Katona Csaba Paizs György T. Balogh László Poppe Diána Balogh-Weiser |
| author_facet | Balázs Decsi Réka Krammer Kristóf Hegedűs Ferenc Ender Benjámin Gyarmati András Szilágyi Róbert Tőtős Gabriel Katona Csaba Paizs György T. Balogh László Poppe Diána Balogh-Weiser |
| author_sort | Balázs Decsi |
| collection | DOAJ |
| description | Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH<sub>2</sub>) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip). |
| first_indexed | 2024-12-23T19:48:30Z |
| format | Article |
| id | doaj.art-a591566aa60a4e92a87625f74c1059df |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-23T19:48:30Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a591566aa60a4e92a87625f74c1059df2022-12-21T17:33:27ZengMDPI AGMicromachines2072-666X2019-10-01101066810.3390/mi10100668mi10100668Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip ReactorBalázs Decsi0Réka Krammer1Kristóf Hegedűs2Ferenc Ender3Benjámin Gyarmati4András Szilágyi5Róbert Tőtős6Gabriel Katona7Csaba Paizs8György T. Balogh9László Poppe10Diána Balogh-Weiser11Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungarySpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, HungarySpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, HungaryDepartment of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungaryDepartment of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungaryBiocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, RomaniaBiocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, RomaniaBiocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, RomaniaDepartment of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, HungaryBiomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH<sub>2</sub>) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).https://www.mdpi.com/2072-666X/10/10/668drug metabolismbiomimetic oxidationmicrofluidicsorgan-on-a-chipliver-on-a-chip |
| spellingShingle | Balázs Decsi Réka Krammer Kristóf Hegedűs Ferenc Ender Benjámin Gyarmati András Szilágyi Róbert Tőtős Gabriel Katona Csaba Paizs György T. Balogh László Poppe Diána Balogh-Weiser Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor Micromachines drug metabolism biomimetic oxidation microfluidics organ-on-a-chip liver-on-a-chip |
| title | Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor |
| title_full | Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor |
| title_fullStr | Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor |
| title_full_unstemmed | Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor |
| title_short | Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor |
| title_sort | liver on a chip magnetic nanoparticle bound synthetic metalloporphyrin catalyzed biomimetic oxidation of a drug in a magnechip reactor |
| topic | drug metabolism biomimetic oxidation microfluidics organ-on-a-chip liver-on-a-chip |
| url | https://www.mdpi.com/2072-666X/10/10/668 |
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