Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying mechanisms and therapeutic potential are incompletely defined.METHODS We explored the underlying biology in myeloid cells from healthy volunte...

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Bibliographic Details
Main Authors: Jing Wu, Komudi Singh, Amy Lin, Allison M. Meadows, Kaiyuan Wu, Vivian Shing, Maximilian Bley, Shahin Hassanzadeh, Rebecca D. Huffstutler, Mark S. Schmidt, Luz P. Blanco, Rong Tian, Charles Brenner, Mehdi Pirooznia, Mariana J. Kaplan, Michael N. Sack
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-03-01
Series:The Journal of Clinical Investigation
Subjects:
Inflammation
Metabolism
Online Access:https://doi.org/10.1172/JCI139828

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