DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients

DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients

Aneuploidy is a consequence of chromosomal instability (CIN) that affects prognosis. Gene expression levels associated with aneuploidy provide insight into the molecular mechanisms underlying CIN. Based on the gene signature whose expression was consistent with functional aneuploidy, the CIN70 score...

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Bibliographic Details
Main Authors: Ioan T. Bold, Ann-Kathrin Specht, Conrad F. Droste, Alexandra Zielinski, Felix Meyer, Till S. Clauditz, Adrian Münscher, Stefan Werner, Kai Rothkamm, Cordula Petersen, Kerstin Borgmann
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
chromosomal instability (CIN)
CIN70 score
replication stress
Chk1 inhibition
HNSCC
radiotherapy
Online Access:https://www.mdpi.com/2072-6694/13/6/1194

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