Effect of oral vitamin K prophylaxis on prothrombine time and activated partial thromboplastin time: a randomized controlled comparison with an intramuscular vitamin K in infants
Background Low plasma concentration of vitamin K in the newborn accounts for serious bleeding in the neonatal period and early infancy. The aim of prophylactic vitamin K is to prevent bleeding. Oral prophylaxis is preferable to intramuscular (IM) administration because oral administration is less ex...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2007-07-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/355 |
| Summary: | Background Low plasma concentration of vitamin K in the
newborn accounts for serious bleeding in the neonatal period and
early infancy. The aim of prophylactic vitamin K is to prevent
bleeding. Oral prophylaxis is preferable to intramuscular (IM)
administration because oral administration is less expensive and
less traumatic.
Objective To compare oral vs. intramuscular vitamin K on
prothrombine time (PT) and activated partial thromboplastin time
(APTT) during the first 60 days of life.
Methods We randomized newborn infants to either receive oral
vitamin K 2 mg at birth and repeated at 7 and 30 days of life or
the 1 mg intramuscular vitamin K. PT and APTT were monitored
at 0, 15, and 45 days of age. Independent t-test, repeated
measurement, and regression analysis were used for statistical
analyses and comparison of the results.
Results Fifty infants were assigned into the oral group and 50 to
the IM group. All participants completed 60 days of study. Both
PT and APTT decreased after administration of oral or IM vitamin
K, and the values did not differ significantly at any time point
and through the period of investigation. Using regression analysis
it was shown that only vitamin K administration was correlated
with PT and APTT with P value were 0.044 and 0.036,
respectively. During 60 days of study, there was no hemorrhagic
diathesis in both groups.
Conclusions Through the first 60 days of life, 3 doses of oral
vitamin K maintain hemostasis by decreasing PT and APTT in
infants at values equal to those achieved by the intramuscular
preparation. Diathesis hemorrhagic event did not occur in both
groups. |
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| ISSN: | 0030-9311 2338-476X |