Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study
Health issues associated with gout and increased occurrence of osteoporosis or fractures have been raised; however, the results are elusive. Herein, we explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data. This study en...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/1/134 |
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| author | Mi Jung Kwon Jae Yong Park Sung Gyun Kim Jwa-Kyung Kim Hyun Lim Joo-Hee Kim Ji Hee Kim Seong-Jin Cho Eun Sook Nam Ha Young Park Nan Young Kim Ho Suk Kang |
| author_facet | Mi Jung Kwon Jae Yong Park Sung Gyun Kim Jwa-Kyung Kim Hyun Lim Joo-Hee Kim Ji Hee Kim Seong-Jin Cho Eun Sook Nam Ha Young Park Nan Young Kim Ho Suk Kang |
| author_sort | Mi Jung Kwon |
| collection | DOAJ |
| description | Health issues associated with gout and increased occurrence of osteoporosis or fractures have been raised; however, the results are elusive. Herein, we explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data. This study enrolled 16,305 patients with gout and 65,220 controls who were matched by propensity score at a 1:4 ratio on the basis of sex, age, income, and residence from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was employed to identify the relevance between gout and incident osteoporosis/fractures, following adjustment for various covariates. In the follow-up period, osteoporosis developed in 761 individuals with gout and 2805 controls (incidence rates: 8.0 and 7.3/1000 person-years, respectively), and each osteoporotic fracture in the distal radius (2.8 vs. 2.7/1000 person-years), hip (1.3 vs. 1.3/1000 person-years), and spine (4.5 vs. 4.5/1000 person-years) occurred in gout and control groups, respectively. After adjustment, the gout group presented an 11% higher development of osteoporosis (95% confidence interval = 1.02–1.20) than the controls (<i>p</i> = 0.011). Subgroup analyses maintained the augment of incident osteoporosis in sufferers with gout, particularly in either men or <60 years. However, no such relevance was identified between gout and incident osteoporotic fractures at any site. In conclusion, gout may result in a slightly elevated likelihood of developing osteoporosis, and not osteoporotic fractures, in the Korean population. |
| first_indexed | 2024-03-09T03:28:38Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:28:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a5933f3fffbe42dd817f9f66a0daa9552023-12-03T14:59:38ZengMDPI AGNutrients2072-66432022-12-0115113410.3390/nu15010134Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up StudyMi Jung Kwon0Jae Yong Park1Sung Gyun Kim2Jwa-Kyung Kim3Hyun Lim4Joo-Hee Kim5Ji Hee Kim6Seong-Jin Cho7Eun Sook Nam8Ha Young Park9Nan Young Kim10Ho Suk Kang11Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Orthopedic Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Internal Medicine, Division of Nephrology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Internal Medicine, Division of Nephrology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Internal Medicine, Division of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Neurosurgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, Republic of KoreaDepartment of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, Republic of KoreaDepartment of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan 47392, Republic of KoreaHallym Institute of Translational Genomics and Bioinformatics, Hallym University Medical Center, Anyang 14068, Republic of KoreaDepartment of Internal Medicine, Division of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaHealth issues associated with gout and increased occurrence of osteoporosis or fractures have been raised; however, the results are elusive. Herein, we explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data. This study enrolled 16,305 patients with gout and 65,220 controls who were matched by propensity score at a 1:4 ratio on the basis of sex, age, income, and residence from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was employed to identify the relevance between gout and incident osteoporosis/fractures, following adjustment for various covariates. In the follow-up period, osteoporosis developed in 761 individuals with gout and 2805 controls (incidence rates: 8.0 and 7.3/1000 person-years, respectively), and each osteoporotic fracture in the distal radius (2.8 vs. 2.7/1000 person-years), hip (1.3 vs. 1.3/1000 person-years), and spine (4.5 vs. 4.5/1000 person-years) occurred in gout and control groups, respectively. After adjustment, the gout group presented an 11% higher development of osteoporosis (95% confidence interval = 1.02–1.20) than the controls (<i>p</i> = 0.011). Subgroup analyses maintained the augment of incident osteoporosis in sufferers with gout, particularly in either men or <60 years. However, no such relevance was identified between gout and incident osteoporotic fractures at any site. In conclusion, gout may result in a slightly elevated likelihood of developing osteoporosis, and not osteoporotic fractures, in the Korean population.https://www.mdpi.com/2072-6643/15/1/134goutosteoporosisosteoporotic fracturerisk factornationwide health care datalongitudinal follow-up study |
| spellingShingle | Mi Jung Kwon Jae Yong Park Sung Gyun Kim Jwa-Kyung Kim Hyun Lim Joo-Hee Kim Ji Hee Kim Seong-Jin Cho Eun Sook Nam Ha Young Park Nan Young Kim Ho Suk Kang Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study Nutrients gout osteoporosis osteoporotic fracture risk factor nationwide health care data longitudinal follow-up study |
| title | Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study |
| title_full | Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study |
| title_fullStr | Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study |
| title_full_unstemmed | Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study |
| title_short | Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study |
| title_sort | potential association of osteoporosis and not osteoporotic fractures in patients with gout a longitudinal follow up study |
| topic | gout osteoporosis osteoporotic fracture risk factor nationwide health care data longitudinal follow-up study |
| url | https://www.mdpi.com/2072-6643/15/1/134 |
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