Interleukin-5 levels in relation to malaria severity: a systematic review
Abstract Background The role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the diseas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-023-04659-3 |
| _version_ | 1797453825170210816 |
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| author | Manas Kotepui Thitinat Duangchan Aongart Mahittikorn Chusana Mekhora Nsoh Godwin Anabire Kwuntida Uthaisar Kotepui |
| author_facet | Manas Kotepui Thitinat Duangchan Aongart Mahittikorn Chusana Mekhora Nsoh Godwin Anabire Kwuntida Uthaisar Kotepui |
| author_sort | Manas Kotepui |
| collection | DOAJ |
| description | Abstract Background The role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the disease. Methods This systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022368773). Searches for studies that reported IL-5 levels in patients with malaria (any severity) and/or uninfected individuals were performed in Web of Science, PubMed, EMBASE, Scopus, CENTRAL, and MEDLINE, between 1st and 10th October, 2022. The risk of bias among all included studies was minimized using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies. The differences in IL-5 levels between malaria and uninfected controls, and between severe and uncomplicated malaria were synthesized by narrative synthesis. Results Among 1177 articles identified in the databases, 23 matched the eligibility criteria and were included in this systematic review. Qualitative syntheses showed the heterogeneity of IL-5 levels between different severities of clinical malaria and uninfected controls. The majority of the included studies (12/15 studies, 80%) found no change in IL-5 levels between malaria cases and uninfected controls. Similarly, most studies found no difference in IL-5 levels between severe (regardless of complications) and uncomplicated malaria (4/8 studies, 50%). The qualitative syntheses revealed that most studies found no difference in IL-5 levels between severe and non-severe malaria. Conclusions The comprehensive review suggests that IL-5 levels are unchanged in patients with different levels of clinical severity of malaria and uninfected controls. Given the limited number of published studies on IL-5 levels in malaria, there is a need for additional research to determine the function of this cytokine in the pathogenesis of malaria. |
| first_indexed | 2024-03-09T15:28:27Z |
| format | Article |
| id | doaj.art-a593f1795fd049b8a1148d1be661ce30 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-03-09T15:28:27Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-a593f1795fd049b8a1148d1be661ce302023-11-26T12:24:02ZengBMCMalaria Journal1475-28752023-08-012211810.1186/s12936-023-04659-3Interleukin-5 levels in relation to malaria severity: a systematic reviewManas Kotepui0Thitinat Duangchan1Aongart Mahittikorn2Chusana Mekhora3Nsoh Godwin Anabire4Kwuntida Uthaisar Kotepui5Medical Technology Program, School of Allied Health Sciences, Walailak UniversityMedical Technology Program, School of Allied Health Sciences, Walailak UniversityDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol UniversityDepartment of Nutrition and Health, Institute of Food Research and Product Development, Kasetsart UniversityDepartment of Biochemistry & Molecular Medicine, School of Medicine, University for Development StudiesMedical Technology Program, School of Allied Health Sciences, Walailak UniversityAbstract Background The role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the disease. Methods This systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022368773). Searches for studies that reported IL-5 levels in patients with malaria (any severity) and/or uninfected individuals were performed in Web of Science, PubMed, EMBASE, Scopus, CENTRAL, and MEDLINE, between 1st and 10th October, 2022. The risk of bias among all included studies was minimized using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies. The differences in IL-5 levels between malaria and uninfected controls, and between severe and uncomplicated malaria were synthesized by narrative synthesis. Results Among 1177 articles identified in the databases, 23 matched the eligibility criteria and were included in this systematic review. Qualitative syntheses showed the heterogeneity of IL-5 levels between different severities of clinical malaria and uninfected controls. The majority of the included studies (12/15 studies, 80%) found no change in IL-5 levels between malaria cases and uninfected controls. Similarly, most studies found no difference in IL-5 levels between severe (regardless of complications) and uncomplicated malaria (4/8 studies, 50%). The qualitative syntheses revealed that most studies found no difference in IL-5 levels between severe and non-severe malaria. Conclusions The comprehensive review suggests that IL-5 levels are unchanged in patients with different levels of clinical severity of malaria and uninfected controls. Given the limited number of published studies on IL-5 levels in malaria, there is a need for additional research to determine the function of this cytokine in the pathogenesis of malaria.https://doi.org/10.1186/s12936-023-04659-3MalariaSevereUncomplicatedComplicatedIL-5Interleukin |
| spellingShingle | Manas Kotepui Thitinat Duangchan Aongart Mahittikorn Chusana Mekhora Nsoh Godwin Anabire Kwuntida Uthaisar Kotepui Interleukin-5 levels in relation to malaria severity: a systematic review Malaria Journal Malaria Severe Uncomplicated Complicated IL-5 Interleukin |
| title | Interleukin-5 levels in relation to malaria severity: a systematic review |
| title_full | Interleukin-5 levels in relation to malaria severity: a systematic review |
| title_fullStr | Interleukin-5 levels in relation to malaria severity: a systematic review |
| title_full_unstemmed | Interleukin-5 levels in relation to malaria severity: a systematic review |
| title_short | Interleukin-5 levels in relation to malaria severity: a systematic review |
| title_sort | interleukin 5 levels in relation to malaria severity a systematic review |
| topic | Malaria Severe Uncomplicated Complicated IL-5 Interleukin |
| url | https://doi.org/10.1186/s12936-023-04659-3 |
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