Association between angiotensin-converting enzyme gene polymorphism and diabetic retinopathy in the Chinese population
Objective : The angiotensin-converting enzyme ( ACE ) gene has been implicated in the development of diabetic retinopathy (DR). However, the results have been conflicting. In this study, we performed a meta-analysis to assess the association of insertion/deletion (I/D) polymorphism in the ACE gene w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2012-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320311432187 |
| Summary: | Objective : The angiotensin-converting enzyme ( ACE ) gene has been implicated in the development of diabetic retinopathy (DR). However, the results have been conflicting. In this study, we performed a meta-analysis to assess the association of insertion/deletion (I/D) polymorphism in the ACE gene with DR in the Chinese population. Methods : Published literature from PubMed, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Results : Seventeen studies (1039 cases and 1185 controls) for I/D polymorphism in the ACE gene were identified. The results suggested that I/D polymorphism D allele might increase the risk of DR (DD vs. II: OR = 1.73, 95% CI 1.19–2.51; DD+ID vs. II: OR = 1.41, 95% CI 1.16–1.72; DD vs. ID+II: OR = 1.55, 95% CI 1.13–2.12). Subgroup analyses based on the type of DR showed that the effect size was statistically significant for proliferative DR (PDR) (DD vs. II: OR = 2.67, 95% CI 1.53–4.64; DD+ID vs. II: OR = 1.86, 95% CI 1.18–2.93; DD vs. ID+II: OR = 2.22, 95% CI 1.38–3.55), but not for background DR (BDR) (DD vs. II: OR = 1.38, 95% CI 0.85–2.25; DD+ID vs. II: OR = 1.40, 95% CI 0.98–2.02; DD vs. ID+II: OR = 1.15, 95% CI 0.74–1.79). Conclusion : The results indicated that I/D polymorphism in the ACE gene was associated with PDR, but not with BDR in the Chinese population. |
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| ISSN: | 1470-3203 1752-8976 |