Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment
Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecular changes in CRC: chromosomal instability, CpG isl...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624001577 |
| _version_ | 1797234353793662976 |
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| author | Rehanoddin Shaikh Sankha Bhattacharya Bhuphendra G. Prajapati |
| author_facet | Rehanoddin Shaikh Sankha Bhattacharya Bhuphendra G. Prajapati |
| author_sort | Rehanoddin Shaikh |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecular changes in CRC: chromosomal instability, CpG island methylator phenotype, and microsatellite instability (MSI). MSI is an uncommon molecular change generated by a malfunctioning DNA mismatch repair (MMR) system. It occurs in approximately 15–20% of CRC patients. In CRC, MSI has significant prognostic and therapeutic implications. MSI-positive CRC patients have a better prognosis and are more likely to react to treatment. MSI can also be used to identify and categorise CRC tumours. |
| first_indexed | 2024-04-24T16:30:43Z |
| format | Article |
| id | doaj.art-a594d66f3b9a476d986c1012cada4b9c |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-24T16:30:43Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-a594d66f3b9a476d986c1012cada4b9c2024-03-30T04:39:07ZengElsevierResults in Chemistry2211-71562024-01-017101461Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatmentRehanoddin Shaikh0Sankha Bhattacharya1Bhuphendra G. Prajapati2Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM’S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, IndiaDepartment of Pharmaceutics, School of Pharmacy & Technology Management, SVKM’S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India; Corresponding authors.Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, 22 Kherva, 384012, India; Corresponding authors.Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecular changes in CRC: chromosomal instability, CpG island methylator phenotype, and microsatellite instability (MSI). MSI is an uncommon molecular change generated by a malfunctioning DNA mismatch repair (MMR) system. It occurs in approximately 15–20% of CRC patients. In CRC, MSI has significant prognostic and therapeutic implications. MSI-positive CRC patients have a better prognosis and are more likely to react to treatment. MSI can also be used to identify and categorise CRC tumours.http://www.sciencedirect.com/science/article/pii/S2211715624001577Microsatellite instability (MSI)Hereditary nonpolyposis colorectal cancer (HNPCC)Chromosomal instability (CIN)CpG island methylator phenotype (CIMP)Prognostic factorsSurveillance |
| spellingShingle | Rehanoddin Shaikh Sankha Bhattacharya Bhuphendra G. Prajapati Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment Results in Chemistry Microsatellite instability (MSI) Hereditary nonpolyposis colorectal cancer (HNPCC) Chromosomal instability (CIN) CpG island methylator phenotype (CIMP) Prognostic factors Surveillance |
| title | Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment |
| title_full | Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment |
| title_fullStr | Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment |
| title_full_unstemmed | Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment |
| title_short | Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatment |
| title_sort | microsatellite instability a potential game changer in colorectal cancer diagnosis and treatment |
| topic | Microsatellite instability (MSI) Hereditary nonpolyposis colorectal cancer (HNPCC) Chromosomal instability (CIN) CpG island methylator phenotype (CIMP) Prognostic factors Surveillance |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624001577 |
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