Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study
Abstract This study aimed to investigate the Mg × K product on the mortality risk of hemodialysis patients with concomitant hypokalemia and lower magnesium levels. This was a prospective observational study of patients in a HD center in southern Taiwan. A total of 444 HD patients were divided into 5...
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49372-y |
| _version_ | 1797388361129787392 |
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| author | Jui-Yi Chen Ming-Yan Jiang Yun-Ting Huang Jyh-Chang Hwang |
| author_facet | Jui-Yi Chen Ming-Yan Jiang Yun-Ting Huang Jyh-Chang Hwang |
| author_sort | Jui-Yi Chen |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the Mg × K product on the mortality risk of hemodialysis patients with concomitant hypokalemia and lower magnesium levels. This was a prospective observational study of patients in a HD center in southern Taiwan. A total of 444 HD patients were divided into 5 groups by the Mg × K product: group 1, bottom quintile, median Mg × K: 7.87, IQR: 7.03–8.12 (n = 89, age: 64 ± 13 years old); group 2, median Mg × K: 9.37, IQR: 8.97–9.86 (n = 89, age:62 ± 13 years old); group 3, median Mg × K: 10.95, IQR: 10.50–11.26 (n = 89, age:64 ± 13 years old); group 4, median Mg × K: 12.30, IQR: 11.87–12.82 (n = 89, 61 ± 12 years old); and group 5, top quintile, median Mg × K: 14.92, IQR:14.07–16.23 (n = 88, 62 ± 11 years old). The patients were followed up for 2 years to determine the risk of all-cause mortality. Patients with a lower Mg × K product had more comorbidities, malnutrition-inflammation status, and a higher mortality risk. Using multivariable Cox regression analysis, a higher Mg × K [HR, 0.89; 95%CI (0.81–0.98)] was found to be an independent predictor of better survival. HD patients with a lower Mg × K product had more comorbidities, a marked malnutrition-inflammation status, and were associated with long-term mortality. A higher Mg × K value is a favorable survival factor. |
| first_indexed | 2024-03-08T22:39:40Z |
| format | Article |
| id | doaj.art-a595287b87a94cb1838decc379467f32 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:39:40Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a595287b87a94cb1838decc379467f322023-12-17T12:16:07ZengNature PortfolioScientific Reports2045-23222023-12-011311910.1038/s41598-023-49372-yLower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort studyJui-Yi Chen0Ming-Yan Jiang1Yun-Ting Huang2Jyh-Chang Hwang3Division of Nephrology, Department of Internal Medicine, Chi Mei Medical CenterDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical CenterDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical CenterDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical CenterAbstract This study aimed to investigate the Mg × K product on the mortality risk of hemodialysis patients with concomitant hypokalemia and lower magnesium levels. This was a prospective observational study of patients in a HD center in southern Taiwan. A total of 444 HD patients were divided into 5 groups by the Mg × K product: group 1, bottom quintile, median Mg × K: 7.87, IQR: 7.03–8.12 (n = 89, age: 64 ± 13 years old); group 2, median Mg × K: 9.37, IQR: 8.97–9.86 (n = 89, age:62 ± 13 years old); group 3, median Mg × K: 10.95, IQR: 10.50–11.26 (n = 89, age:64 ± 13 years old); group 4, median Mg × K: 12.30, IQR: 11.87–12.82 (n = 89, 61 ± 12 years old); and group 5, top quintile, median Mg × K: 14.92, IQR:14.07–16.23 (n = 88, 62 ± 11 years old). The patients were followed up for 2 years to determine the risk of all-cause mortality. Patients with a lower Mg × K product had more comorbidities, malnutrition-inflammation status, and a higher mortality risk. Using multivariable Cox regression analysis, a higher Mg × K [HR, 0.89; 95%CI (0.81–0.98)] was found to be an independent predictor of better survival. HD patients with a lower Mg × K product had more comorbidities, a marked malnutrition-inflammation status, and were associated with long-term mortality. A higher Mg × K value is a favorable survival factor.https://doi.org/10.1038/s41598-023-49372-y |
| spellingShingle | Jui-Yi Chen Ming-Yan Jiang Yun-Ting Huang Jyh-Chang Hwang Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study Scientific Reports |
| title | Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study |
| title_full | Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study |
| title_fullStr | Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study |
| title_full_unstemmed | Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study |
| title_short | Lower product of magnesium × potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study |
| title_sort | lower product of magnesium potassium is associated with higher mortality in chronic hemodialysis patients a cohort study |
| url | https://doi.org/10.1038/s41598-023-49372-y |
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