Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration
N6-methyladenosine (m<sup>6</sup>A), the most abundant modification in messenger RNAs (mRNAs), is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by demethylases (“erasers”) Fto and Alkbh5. m<sup>6</sup>A can be recognized by m<sup>6</sup>...
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2694 |
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| author | Liqi Shu Xiaoli Huang Xuejun Cheng Xuekun Li |
| author_facet | Liqi Shu Xiaoli Huang Xuejun Cheng Xuekun Li |
| author_sort | Liqi Shu |
| collection | DOAJ |
| description | N6-methyladenosine (m<sup>6</sup>A), the most abundant modification in messenger RNAs (mRNAs), is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by demethylases (“erasers”) Fto and Alkbh5. m<sup>6</sup>A can be recognized by m<sup>6</sup>A-binding proteins (“readers”), such as Yth domain family proteins (Ythdfs) and Yth domain-containing protein 1 (Ythdc1). Previous studies have indicated that m<sup>6</sup>A plays an essential function in various fundamental biological processes, including neurogenesis and neuronal development. Dysregulated m<sup>6</sup>A modification contributes to neurological disorders, including neurodegenerative diseases. In this review, we summarize the current knowledge about the roles of m<sup>6</sup>A machinery, including writers, erasers, and readers, in regulating gene expression and the function of m<sup>6</sup>A in neurodevelopment and neurodegeneration. We also discuss the perspectives for studying m<sup>6</sup>A methylation. |
| first_indexed | 2024-03-10T06:39:44Z |
| format | Article |
| id | doaj.art-a5962f799f5d421f84264b8f03448a26 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:44Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a5962f799f5d421f84264b8f03448a262023-11-22T17:47:41ZengMDPI AGCells2073-44092021-10-011010269410.3390/cells10102694Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and NeurodegenerationLiqi Shu0Xiaoli Huang1Xuejun Cheng2Xuekun Li3Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI 02908, USAThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, ChinaThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, ChinaThe Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, ChinaN6-methyladenosine (m<sup>6</sup>A), the most abundant modification in messenger RNAs (mRNAs), is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by demethylases (“erasers”) Fto and Alkbh5. m<sup>6</sup>A can be recognized by m<sup>6</sup>A-binding proteins (“readers”), such as Yth domain family proteins (Ythdfs) and Yth domain-containing protein 1 (Ythdc1). Previous studies have indicated that m<sup>6</sup>A plays an essential function in various fundamental biological processes, including neurogenesis and neuronal development. Dysregulated m<sup>6</sup>A modification contributes to neurological disorders, including neurodegenerative diseases. In this review, we summarize the current knowledge about the roles of m<sup>6</sup>A machinery, including writers, erasers, and readers, in regulating gene expression and the function of m<sup>6</sup>A in neurodevelopment and neurodegeneration. We also discuss the perspectives for studying m<sup>6</sup>A methylation.https://www.mdpi.com/2073-4409/10/10/2694N6-methyladenosineMettl3Mettl14FtoYthdf1neurodevelopment |
| spellingShingle | Liqi Shu Xiaoli Huang Xuejun Cheng Xuekun Li Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration Cells N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment |
| title | Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration |
| title_full | Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration |
| title_fullStr | Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration |
| title_full_unstemmed | Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration |
| title_short | Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration |
| title_sort | emerging roles of n6 methyladenosine modification in neurodevelopment and neurodegeneration |
| topic | N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment |
| url | https://www.mdpi.com/2073-4409/10/10/2694 |
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