A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell proliferation by down-regulation of cyclin D1 and TGF-β1

A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell proliferation by down-regulation of cyclin D1 and TGF-β1

We have demonstrated that a synthetic DNA enzyme targeting early growth response factor-1 (Egr-1) can inhibit neointimal hyperplasia following vascular injury. However, the detailed mechanism of this inhibition is not known. Thus, the objective of the present study was to further investigate potenti...

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Bibliographic Details
Main Authors:	Y. Wu, W. Han, G.-N. Liu
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2010-01-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	DNA enzyme Egr-1 VSMC Proliferation Apoptosis
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100004&lng=en&tlng=en

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