Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres
A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical...
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MDPI AG
2015-09-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/9/5901 |
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| author | Niuris Acosta Elisa Sánchez Laura Calderón Manuel Cordoba-Diaz Damián Cordoba-Diaz Senne Dom Ángeles Heras |
| author_facet | Niuris Acosta Elisa Sánchez Laura Calderón Manuel Cordoba-Diaz Damián Cordoba-Diaz Senne Dom Ángeles Heras |
| author_sort | Niuris Acosta |
| collection | DOAJ |
| description | A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5. |
| first_indexed | 2024-04-14T07:00:27Z |
| format | Article |
| id | doaj.art-a598e80d8000481aaf916857b2cc8977 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T07:00:27Z |
| publishDate | 2015-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a598e80d8000481aaf916857b2cc89772022-12-22T02:06:46ZengMDPI AGMarine Drugs1660-33972015-09-011395901591910.3390/md13095901md13095901Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan MicrospheresNiuris Acosta0Elisa Sánchez1Laura Calderón2Manuel Cordoba-Diaz3Damián Cordoba-Diaz4Senne Dom5Ángeles Heras6Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, SpainDepartment of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, SpainDepartment of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, SpainDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, SpainDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, SpainDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, SpainDepartment of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, SpainA chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5.http://www.mdpi.com/1660-3397/13/9/5901chitosanspray-dryingsemi-solid formulationantioxidant encapsulation |
| spellingShingle | Niuris Acosta Elisa Sánchez Laura Calderón Manuel Cordoba-Diaz Damián Cordoba-Diaz Senne Dom Ángeles Heras Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres Marine Drugs chitosan spray-drying semi-solid formulation antioxidant encapsulation |
| title | Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres |
| title_full | Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres |
| title_fullStr | Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres |
| title_full_unstemmed | Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres |
| title_short | Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres |
| title_sort | physical stability studies of semi solid formulations from natural compounds loaded with chitosan microspheres |
| topic | chitosan spray-drying semi-solid formulation antioxidant encapsulation |
| url | http://www.mdpi.com/1660-3397/13/9/5901 |
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