Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence
Background: TBI is a major global health issue due to its high morbidity and mortality rates. Persistent neurodegeneration following secondary brain injuries is a significant concern. Trehalose, a naturally occurring disaccharide, has shown potential therapeutic effects in preclinical TBI models. Th...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Interdisciplinary Neurosurgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475192300230X |
| _version_ | 1797259952479272960 |
|---|---|
| author | Mohammad Ghorbani MohammadAli Abouei Mehrizi Mahboobeh Tajvidi Mohmmad Amin Habibi Mohammad Mohammadi Saeid Esmaeilian Paria Torabi Elham Rahmanipour Mahyar Daskareh Aynaz Mohammadi |
| author_facet | Mohammad Ghorbani MohammadAli Abouei Mehrizi Mahboobeh Tajvidi Mohmmad Amin Habibi Mohammad Mohammadi Saeid Esmaeilian Paria Torabi Elham Rahmanipour Mahyar Daskareh Aynaz Mohammadi |
| author_sort | Mohammad Ghorbani |
| collection | DOAJ |
| description | Background: TBI is a major global health issue due to its high morbidity and mortality rates. Persistent neurodegeneration following secondary brain injuries is a significant concern. Trehalose, a naturally occurring disaccharide, has shown potential therapeutic effects in preclinical TBI models. This study systematically reviews the preclinical and clinical data on trehalose as a potential TBI treatment. Methods: We conducted a systematic review of trehalose’s role in TBI treatment following PRISMA guidelines. Our search spanned from the inception of PubMed, EMBASE, SCOPUS, and Web of Science until August 2023. Google Scholar was also manually searched. The quality of the studies was assessed using SYRCLE’s risk of bias tool for animal studies. Results: Out of sixty-six records reviewed, four animal studies were included. These studies indicated that trehalose enhanced motor and cognitive functions, reduced oxidative damage and inflammation, regulated metal dyshomeostasis, increased neurotrophic factors and synaptic proteins, and improved autophagy and mitochondrial function in mouse/rat TBI models. However, a significant risk of bias was noted. Conclusion: Trehalose demonstrates potential as a TBI treatment. However, more rigorous, and comprehensive research is needed to confirm its safety and efficacy in humans. |
| first_indexed | 2024-03-08T18:18:48Z |
| format | Article |
| id | doaj.art-a5990f8e7c914d9587cf0f82f5de5782 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-24T23:17:36Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-a5990f8e7c914d9587cf0f82f5de57822024-03-17T07:54:19ZengElsevierInterdisciplinary Neurosurgery2214-75192024-06-0136101947Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidenceMohammad Ghorbani0MohammadAli Abouei Mehrizi1Mahboobeh Tajvidi2Mohmmad Amin Habibi3Mohammad Mohammadi4Saeid Esmaeilian5Paria Torabi6Elham Rahmanipour7Mahyar Daskareh8Aynaz Mohammadi9Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Orthopedic Research Center, Mashhad University of Medical Sciences, The East Door of The University Campus, Azadi Square, Mashhad, Khorasan Razavi, Iran.Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran; Surgical Research Society (SRS), Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, IranTehran Medical Branch, Islamic Azad University, Tehran, IranFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Radiology, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Iran University of Medical Sciences, Tehran, IranBackground: TBI is a major global health issue due to its high morbidity and mortality rates. Persistent neurodegeneration following secondary brain injuries is a significant concern. Trehalose, a naturally occurring disaccharide, has shown potential therapeutic effects in preclinical TBI models. This study systematically reviews the preclinical and clinical data on trehalose as a potential TBI treatment. Methods: We conducted a systematic review of trehalose’s role in TBI treatment following PRISMA guidelines. Our search spanned from the inception of PubMed, EMBASE, SCOPUS, and Web of Science until August 2023. Google Scholar was also manually searched. The quality of the studies was assessed using SYRCLE’s risk of bias tool for animal studies. Results: Out of sixty-six records reviewed, four animal studies were included. These studies indicated that trehalose enhanced motor and cognitive functions, reduced oxidative damage and inflammation, regulated metal dyshomeostasis, increased neurotrophic factors and synaptic proteins, and improved autophagy and mitochondrial function in mouse/rat TBI models. However, a significant risk of bias was noted. Conclusion: Trehalose demonstrates potential as a TBI treatment. However, more rigorous, and comprehensive research is needed to confirm its safety and efficacy in humans.http://www.sciencedirect.com/science/article/pii/S221475192300230XTBITraumatic brain injuryTrehaloseAnimal models |
| spellingShingle | Mohammad Ghorbani MohammadAli Abouei Mehrizi Mahboobeh Tajvidi Mohmmad Amin Habibi Mohammad Mohammadi Saeid Esmaeilian Paria Torabi Elham Rahmanipour Mahyar Daskareh Aynaz Mohammadi Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence Interdisciplinary Neurosurgery TBI Traumatic brain injury Trehalose Animal models |
| title | Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence |
| title_full | Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence |
| title_fullStr | Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence |
| title_full_unstemmed | Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence |
| title_short | Trehalose: A promising new treatment for traumatic brain injury? A systematic review of animal evidence |
| title_sort | trehalose a promising new treatment for traumatic brain injury a systematic review of animal evidence |
| topic | TBI Traumatic brain injury Trehalose Animal models |
| url | http://www.sciencedirect.com/science/article/pii/S221475192300230X |
| work_keys_str_mv | AT mohammadghorbani trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT mohammadaliaboueimehrizi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT mahboobehtajvidi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT mohmmadaminhabibi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT mohammadmohammadi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT saeidesmaeilian trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT pariatorabi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT elhamrahmanipour trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT mahyardaskareh trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence AT aynazmohammadi trehaloseapromisingnewtreatmentfortraumaticbraininjuryasystematicreviewofanimalevidence |