Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319302415 |
| _version_ | 1818422758083657728 |
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| author | Kazumasa Horikawa Kazuyuki Fuji Yuka Fukazawa Shigenobu Shibata |
| author_facet | Kazumasa Horikawa Kazuyuki Fuji Yuka Fukazawa Shigenobu Shibata |
| author_sort | Kazumasa Horikawa |
| collection | DOAJ |
| description | Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock. Keywords:: circadian clock, serotonin, non-photic |
| first_indexed | 2024-12-14T13:31:20Z |
| format | Article |
| id | doaj.art-a59a50b3405f40408bcd8f5320355226 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-14T13:31:20Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-a59a50b3405f40408bcd8f53203552262022-12-21T22:59:42ZengElsevierJournal of Pharmacological Sciences1347-86132013-01-011234402406Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian ClockKazumasa Horikawa0Kazuyuki Fuji1Yuka Fukazawa2Shigenobu Shibata3Advanced Research Center for Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanDepartment of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanDepartment of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo 162-8480, JapanAdvanced Research Center for Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan; Corresponding author. shibatas@waseda.jpSeveral lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock. Keywords:: circadian clock, serotonin, non-photichttp://www.sciencedirect.com/science/article/pii/S1347861319302415 |
| spellingShingle | Kazumasa Horikawa Kazuyuki Fuji Yuka Fukazawa Shigenobu Shibata Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock Journal of Pharmacological Sciences |
| title | Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock |
| title_full | Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock |
| title_fullStr | Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock |
| title_full_unstemmed | Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock |
| title_short | Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock |
| title_sort | two distinct serotonin receptors co mediate non photic signals to the circadian clock |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319302415 |
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