Reprogramming—Evolving Path to Functional Surrogate β-Cells
Numerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/18/2813 |
| _version_ | 1797490149766987776 |
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| author | Eric Kalo Scott Read Golo Ahlenstiel |
| author_facet | Eric Kalo Scott Read Golo Ahlenstiel |
| author_sort | Eric Kalo |
| collection | DOAJ |
| description | Numerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages into insulin-secreting β-cells. In this review, we explore emerging reprograming pathways that aim to generate bone fide insulin producing cells. We focus on small molecules and key transcriptional regulators that orchestrate phenotypic conversion and maintenance of engineered cells. |
| first_indexed | 2024-03-10T00:26:53Z |
| format | Article |
| id | doaj.art-a59be7acc37f404aba15b562bf6f2b7c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:26:53Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a59be7acc37f404aba15b562bf6f2b7c2023-11-23T15:32:40ZengMDPI AGCells2073-44092022-09-011118281310.3390/cells11182813Reprogramming—Evolving Path to Functional Surrogate β-CellsEric Kalo0Scott Read1Golo Ahlenstiel2Blacktown Clinical School and Research Centre, School of Medicine, Western Sydney University, Blacktown, NSW 2148, AustraliaBlacktown Clinical School and Research Centre, School of Medicine, Western Sydney University, Blacktown, NSW 2148, AustraliaBlacktown Clinical School and Research Centre, School of Medicine, Western Sydney University, Blacktown, NSW 2148, AustraliaNumerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages into insulin-secreting β-cells. In this review, we explore emerging reprograming pathways that aim to generate bone fide insulin producing cells. We focus on small molecules and key transcriptional regulators that orchestrate phenotypic conversion and maintenance of engineered cells.https://www.mdpi.com/2073-4409/11/18/2813β-celldiabetes mellituscell sourcesreprogramminginsulin |
| spellingShingle | Eric Kalo Scott Read Golo Ahlenstiel Reprogramming—Evolving Path to Functional Surrogate β-Cells Cells β-cell diabetes mellitus cell sources reprogramming insulin |
| title | Reprogramming—Evolving Path to Functional Surrogate β-Cells |
| title_full | Reprogramming—Evolving Path to Functional Surrogate β-Cells |
| title_fullStr | Reprogramming—Evolving Path to Functional Surrogate β-Cells |
| title_full_unstemmed | Reprogramming—Evolving Path to Functional Surrogate β-Cells |
| title_short | Reprogramming—Evolving Path to Functional Surrogate β-Cells |
| title_sort | reprogramming evolving path to functional surrogate β cells |
| topic | β-cell diabetes mellitus cell sources reprogramming insulin |
| url | https://www.mdpi.com/2073-4409/11/18/2813 |
| work_keys_str_mv | AT erickalo reprogrammingevolvingpathtofunctionalsurrogatebcells AT scottread reprogrammingevolvingpathtofunctionalsurrogatebcells AT goloahlenstiel reprogrammingevolvingpathtofunctionalsurrogatebcells |