Heat-Induced Epithelial Barrier Dysfunction Occurs via C-Src Kinase and P120ctn Expression Regulation in the Lungs

Heat-Induced Epithelial Barrier Dysfunction Occurs via C-Src Kinase and P120ctn Expression Regulation in the Lungs

Background/Aims: Thermal injury causes pulmonary edema and can lead to death. Intercellular junctions are composed of adhesive (p120ctn, E-cadherin, α-catenin and β-catenin) and compact (occludin and ZO-1) junctions. Heat deteriorates intercellular junctions and increases cell gaps to ultimately ind...

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Bibliographic Details
Main Authors: Jie Li, Xiaohu Ren, Lingwei Wang, Xiu Yu, Khalid Khan, Mengjie Feng, Qi He, Huanmin Luo, Chen Qiu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Heat
Thermal inhalation injury
P120ctn
C-Src
Cell junction
Online Access:https://www.karger.com/Article/FullText/491723

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