p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB

p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB

The microenvironment of lymphoid organs is central to the pathogenesis of chronic lymphocytic leukemia (CLL). Within it, tumor cells find a favourable niche to escape immunosurveillance and acquire pro-survival signals. We have previously reported that a CLL-associated defect in the expression of th...

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Bibliographic Details
Main Authors: Vanessa Tatangelo, Gioia Boncompagni, Nagaja Capitani, Ludovica Lopresti, Noemi Manganaro, Federica Frezzato, Andrea Visentin, Livio Trentin, Cosima T. Baldari, Laura Patrussi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
NF-kB
chronic lymphocytic leukemia (CLL)
P66shc
ROS
chemokine receptor
CCR2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.877495/full

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