Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care
An ideal wound dressing should have several qualities to protect the wound from infection and other adverse factors. This study aimed to fabricate a wound care membrane combining the two well-known bioactive agents silver nanoparticles (AgNPs) and chitosan oligosaccharides (COS). In specific, this m...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217923000515 |
| _version_ | 1827860776191262720 |
|---|---|
| author | Tuan-Ngan Tang Thu Hai-Anh Nguyen Chien Minh Tran Vinh Khanh Doan Ngoc Thi-Thanh Nguyen Binh Thanh Vu Nhi Ngoc-Thao Dang Thanh Tu Duong Viet Hung Pham Lam Dai Tran Toi Van Vo Thi-Hiep Nguyen |
| author_facet | Tuan-Ngan Tang Thu Hai-Anh Nguyen Chien Minh Tran Vinh Khanh Doan Ngoc Thi-Thanh Nguyen Binh Thanh Vu Nhi Ngoc-Thao Dang Thanh Tu Duong Viet Hung Pham Lam Dai Tran Toi Van Vo Thi-Hiep Nguyen |
| author_sort | Tuan-Ngan Tang |
| collection | DOAJ |
| description | An ideal wound dressing should have several qualities to protect the wound from infection and other adverse factors. This study aimed to fabricate a wound care membrane combining the two well-known bioactive agents silver nanoparticles (AgNPs) and chitosan oligosaccharides (COS). In specific, this multilayer membrane (PCL-Ag/POX/COS) consisted of (1) the electrospun basement layer of poly(ε-caprolactone) (PCL) and AgNPs; (2) the intermediate amphiphilic layer of PCL and poloxamer 407 (POX); and (3) the coating layer of COS and poly(N-vinyl pyrrolidone) (PVP). Several characterisation tests showed that the membrane was successfully coated with COS and owned suitable characteristics as a wound dressing, including proper tensile strength (more significant than the typical value of the skin), the hydrophilic and fluid-absorbable innermost surface, the waterproof outermost basement, vapour permeability, rapid COS release, and gradual AgNP release. In vitro experiments proved its haemostatic effect and antibacterial activities. Though its 100% extract solution reduced in vitro fibroblast viability, through the skin-defected mouse model experiment, PCL-Ag/POX/COS was compatible with the wound tissue and exhibited several positive effects on wound healing. In conclusion, PCL-Ag/POX/COS was proven for its potential for wound care, but it needs further investigations to allow translation from bench to bedside. |
| first_indexed | 2024-03-12T13:27:43Z |
| format | Article |
| id | doaj.art-a5a234b6db5d4cc8b61016d9fffd359e |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-03-12T13:27:43Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-a5a234b6db5d4cc8b61016d9fffd359e2023-08-25T04:24:31ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792023-09-0183100582Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound careTuan-Ngan Tang0Thu Hai-Anh Nguyen1Chien Minh Tran2Vinh Khanh Doan3Ngoc Thi-Thanh Nguyen4Binh Thanh Vu5Nhi Ngoc-Thao Dang6Thanh Tu Duong7Viet Hung Pham8Lam Dai Tran9Toi Van Vo10Thi-Hiep Nguyen11School of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamDepartment of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 700000, Viet NamKey Laboratory of Analytical Technology for Environmental Quality and Food Safety Control, University of Science, Vietnam National University, Hanoi, Viet NamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet NamSchool of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City, 700000, Viet Nam; Corresponding author. School of Biomedical Engineering, International University, Ho Chi Minh City, 700000, Viet Nam.An ideal wound dressing should have several qualities to protect the wound from infection and other adverse factors. This study aimed to fabricate a wound care membrane combining the two well-known bioactive agents silver nanoparticles (AgNPs) and chitosan oligosaccharides (COS). In specific, this multilayer membrane (PCL-Ag/POX/COS) consisted of (1) the electrospun basement layer of poly(ε-caprolactone) (PCL) and AgNPs; (2) the intermediate amphiphilic layer of PCL and poloxamer 407 (POX); and (3) the coating layer of COS and poly(N-vinyl pyrrolidone) (PVP). Several characterisation tests showed that the membrane was successfully coated with COS and owned suitable characteristics as a wound dressing, including proper tensile strength (more significant than the typical value of the skin), the hydrophilic and fluid-absorbable innermost surface, the waterproof outermost basement, vapour permeability, rapid COS release, and gradual AgNP release. In vitro experiments proved its haemostatic effect and antibacterial activities. Though its 100% extract solution reduced in vitro fibroblast viability, through the skin-defected mouse model experiment, PCL-Ag/POX/COS was compatible with the wound tissue and exhibited several positive effects on wound healing. In conclusion, PCL-Ag/POX/COS was proven for its potential for wound care, but it needs further investigations to allow translation from bench to bedside.http://www.sciencedirect.com/science/article/pii/S2468217923000515BiomaterialWound dressingWound healingElectrospinningSilver nanoparticlesChitosan oligosaccharides |
| spellingShingle | Tuan-Ngan Tang Thu Hai-Anh Nguyen Chien Minh Tran Vinh Khanh Doan Ngoc Thi-Thanh Nguyen Binh Thanh Vu Nhi Ngoc-Thao Dang Thanh Tu Duong Viet Hung Pham Lam Dai Tran Toi Van Vo Thi-Hiep Nguyen Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care Journal of Science: Advanced Materials and Devices Biomaterial Wound dressing Wound healing Electrospinning Silver nanoparticles Chitosan oligosaccharides |
| title | Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| title_full | Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| title_fullStr | Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| title_full_unstemmed | Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| title_short | Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| title_sort | fabrication of silver nanoparticle containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care |
| topic | Biomaterial Wound dressing Wound healing Electrospinning Silver nanoparticles Chitosan oligosaccharides |
| url | http://www.sciencedirect.com/science/article/pii/S2468217923000515 |
| work_keys_str_mv | AT tuanngantang fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT thuhaianhnguyen fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT chienminhtran fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT vinhkhanhdoan fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT ngocthithanhnguyen fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT binhthanhvu fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT nhingocthaodang fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT thanhtuduong fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT viethungpham fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT lamdaitran fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT toivanvo fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare AT thihiepnguyen fabricationofsilvernanoparticlecontainingelectrospunpolycaprolactonemembranecoatedwithchitosanoligosaccharidesforskinwoundcare |