Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex
Purkinje cells (PCs) are large GABAergic projection neurons of the cerebellar cortex, endowed with elaborate dendrites that receive a multitude of excitatory inputs. Being the only efferent neuron of the cerebellar cortex, PCs project to cerebellar nuclei and control behaviors ranging from movement...
Main Authors: | Shahin Shabanipour, Xiaodan Jiao, Maryam Rahimi-Balaei, Mohamad Reza Aghanoori, Seung H. Chung, Saeid Ghavami, G. Giacomo Consalez, Hassan Marzban |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-01-01
|
Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.804402/full |
Similar Items
-
Cell death, glial protein alterations and elevated S-100β release in cerebellar cell cultures following mechanically induced trauma
by: Jennifer E Slemmer, et al.
Published: (2004-04-01) -
Single nuclei RNA sequencing investigation of the Purkinje cell and glial changes in the cerebellum of transgenic Spinocerebellar ataxia type 1 mice
by: Ella Borgenheimer, et al.
Published: (2022-11-01) -
Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1
by: Carmen Nanclares, et al.
Published: (2023-10-01) -
Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice
by: Xiaodan Jiao, et al.
Published: (2021-03-01) -
Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1
by: Anton N. Shuvaev, et al.
Published: (2021-07-01)