Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants
Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography mod...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-07-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731418790694 |
| _version_ | 1828532428682035200 |
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| author | Laila Damiati Marcus G Eales Angela H Nobbs Bo Su Penelope M Tsimbouri Manuel Salmeron-Sanchez Matthew J Dalby |
| author_facet | Laila Damiati Marcus G Eales Angela H Nobbs Bo Su Penelope M Tsimbouri Manuel Salmeron-Sanchez Matthew J Dalby |
| author_sort | Laila Damiati |
| collection | DOAJ |
| description | Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties. |
| first_indexed | 2024-12-11T22:52:00Z |
| format | Article |
| id | doaj.art-a5a64507a5ce4787a78e11a928dbf4cb |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-11T22:52:00Z |
| publishDate | 2018-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-a5a64507a5ce4787a78e11a928dbf4cb2022-12-22T00:47:24ZengSAGE PublishingJournal of Tissue Engineering2041-73142018-07-01910.1177/2041731418790694Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implantsLaila Damiati0Marcus G Eales1Angela H Nobbs2Bo Su3Penelope M Tsimbouri4Manuel Salmeron-Sanchez5Matthew J Dalby6Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UKBristol Dental School, University of Bristol, Bristol, UKBristol Dental School, University of Bristol, Bristol, UKBristol Dental School, University of Bristol, Bristol, UKInstitute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UKDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, UKInstitute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UKTitanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.https://doi.org/10.1177/2041731418790694 |
| spellingShingle | Laila Damiati Marcus G Eales Angela H Nobbs Bo Su Penelope M Tsimbouri Manuel Salmeron-Sanchez Matthew J Dalby Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants Journal of Tissue Engineering |
| title | Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| title_full | Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| title_fullStr | Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| title_full_unstemmed | Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| title_short | Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| title_sort | impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants |
| url | https://doi.org/10.1177/2041731418790694 |
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