CD40 Cross-Linking Induces Migration of Renal Tumor Cell through Nuclear Factor of Activated T Cells (NFAT) Activation

CD40 Cross-Linking Induces Migration of Renal Tumor Cell through Nuclear Factor of Activated T Cells (NFAT) Activation

CD40 crosslinking plays an important role in regulating cell migration, adhesion and proliferation in renal cell carcinoma (RCC). CD40/CD40L interaction on RCC cells activates different intracellular pathways but the molecular mechanisms leading to cell scattering are not yet clearly defined. Aim of...

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Bibliographic Details
Main Authors: Paola Pontrelli, Margherita Gigante, Federica Spadaccino, Giuseppe Stefano Netti, Marilisa Saldarelli, Luigi Balducci, Maddalena Gigante, Michele Battaglia, Walter J. Storkus, Giuseppe Castellano, Giovanni Stallone, Loreto Gesualdo, Elena Ranieri
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
renal cell carcinoma
CD40/CD40L crosslinking
cell migration
NFATs
integrin β1
Online Access:https://www.mdpi.com/1422-0067/22/16/8871

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