Fluorinate polyacrylic acid and its use as a potential adjuvant field
This study describes a polymer potentially used as a vaccine adjuvant. We first synthesized a novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the polyacrylic acid by fluorine. This functionalization could offer a...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2022-01-01
|
| Series: | BIO Web of Conferences |
| Subjects: | |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2022/14/bioconf_fbse2022_01029.pdf |
| _version_ | 1828276077011664896 |
|---|---|
| author | Bai Lu Li Chengyu Zhou Mengmeng Chen Xiaoqi Zhou Haijun Zhang Fen Li Xin Li Yantao |
| author_facet | Bai Lu Li Chengyu Zhou Mengmeng Chen Xiaoqi Zhou Haijun Zhang Fen Li Xin Li Yantao |
| author_sort | Bai Lu |
| collection | DOAJ |
| description | This study describes a polymer potentially used as a vaccine adjuvant. We first synthesized a novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the polyacrylic acid by fluorine. This functionalization could offer a permanent graft by an esterification reaction. The chemical structure of the polymer has been characterized by the hydrogen nuclear magnetic resonance spectrum (1H-NMR) and fourier transform infrared spectrum (FT-IR). Thermal analysis showed that the esterification reaction was successful on the polyacrylic acid. Viscosity testing showed that the viscosity of the sample aqueous solution increases along with esterification. The surface tension of the polymer was also tested. The results show that the surface tension of the polyacrylic acid markedly decreased when modified by fluorine. Finally, the interaction of these materials with macrophages was tested on cell test. Results showed that the modified polyacrylic acid performed better improve the activation effect than pure polyacrylic acid in 1L-1β. |
| first_indexed | 2024-04-13T06:53:23Z |
| format | Article |
| id | doaj.art-a5a7edeff9894e1d965dbb6be29ce18c |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-04-13T06:53:23Z |
| publishDate | 2022-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-a5a7edeff9894e1d965dbb6be29ce18c2022-12-22T02:57:20ZengEDP SciencesBIO Web of Conferences2117-44582022-01-01550102910.1051/bioconf/20225501029bioconf_fbse2022_01029Fluorinate polyacrylic acid and its use as a potential adjuvant fieldBai Lu0Li Chengyu1Zhou Mengmeng2Chen Xiaoqi3Zhou Haijun4Zhang Fen5Li Xin6Li Yantao7Institute of Energy Resources, Hebei Academy of SciencesHebei University of Science and TechnologyInstitute of Energy Resources, Hebei Academy of SciencesInstitute of Energy Resources, Hebei Academy of SciencesInstitute of Energy Resources, Hebei Academy of SciencesInstitute of Energy Resources, Hebei Academy of SciencesInstitute of Energy Resources, Hebei Academy of SciencesInstitute of Energy Resources, Hebei Academy of SciencesThis study describes a polymer potentially used as a vaccine adjuvant. We first synthesized a novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the polyacrylic acid by fluorine. This functionalization could offer a permanent graft by an esterification reaction. The chemical structure of the polymer has been characterized by the hydrogen nuclear magnetic resonance spectrum (1H-NMR) and fourier transform infrared spectrum (FT-IR). Thermal analysis showed that the esterification reaction was successful on the polyacrylic acid. Viscosity testing showed that the viscosity of the sample aqueous solution increases along with esterification. The surface tension of the polymer was also tested. The results show that the surface tension of the polyacrylic acid markedly decreased when modified by fluorine. Finally, the interaction of these materials with macrophages was tested on cell test. Results showed that the modified polyacrylic acid performed better improve the activation effect than pure polyacrylic acid in 1L-1β.https://www.bio-conferences.org/articles/bioconf/pdf/2022/14/bioconf_fbse2022_01029.pdfvaccine adjuvantpolyacrylic acidactivation |
| spellingShingle | Bai Lu Li Chengyu Zhou Mengmeng Chen Xiaoqi Zhou Haijun Zhang Fen Li Xin Li Yantao Fluorinate polyacrylic acid and its use as a potential adjuvant field BIO Web of Conferences vaccine adjuvant polyacrylic acid activation |
| title | Fluorinate polyacrylic acid and its use as a potential adjuvant field |
| title_full | Fluorinate polyacrylic acid and its use as a potential adjuvant field |
| title_fullStr | Fluorinate polyacrylic acid and its use as a potential adjuvant field |
| title_full_unstemmed | Fluorinate polyacrylic acid and its use as a potential adjuvant field |
| title_short | Fluorinate polyacrylic acid and its use as a potential adjuvant field |
| title_sort | fluorinate polyacrylic acid and its use as a potential adjuvant field |
| topic | vaccine adjuvant polyacrylic acid activation |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2022/14/bioconf_fbse2022_01029.pdf |
| work_keys_str_mv | AT bailu fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT lichengyu fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT zhoumengmeng fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT chenxiaoqi fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT zhouhaijun fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT zhangfen fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT lixin fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield AT liyantao fluorinatepolyacrylicacidanditsuseasapotentialadjuvantfield |