Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond
Self-organized neuronal oscillations rely on precisely orchestrated ensemble activity in reverberating neuronal networks. Chronic, non-malignant disorders of the brain are often coupled to pathological neuronal activity patterns. In addition to the characteristic behavioral symptoms, these disturban...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.784085/full |
| _version_ | 1818400375710941184 |
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| author | Tamás Földi Tamás Földi Tamás Földi Tamás Földi Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Antal Berényi Antal Berényi Antal Berényi Antal Berényi |
| author_facet | Tamás Földi Tamás Földi Tamás Földi Tamás Földi Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Antal Berényi Antal Berényi Antal Berényi Antal Berényi |
| author_sort | Tamás Földi |
| collection | DOAJ |
| description | Self-organized neuronal oscillations rely on precisely orchestrated ensemble activity in reverberating neuronal networks. Chronic, non-malignant disorders of the brain are often coupled to pathological neuronal activity patterns. In addition to the characteristic behavioral symptoms, these disturbances are giving rise to both transient and persistent changes of various brain rhythms. Increasing evidence support the causal role of these “oscillopathies” in the phenotypic emergence of the disease symptoms, identifying neuronal network oscillations as potential therapeutic targets. While the kinetics of pharmacological therapy is not suitable to compensate the disease related fine-scale disturbances of network oscillations, external biophysical modalities (e.g., electrical stimulation) can alter spike timing in a temporally precise manner. These perturbations can warp rhythmic oscillatory patterns via resonance or entrainment. Properly timed phasic stimuli can even switch between the stable states of networks acting as multistable oscillators, substantially changing the emergent oscillatory patterns. Novel transcranial electric stimulation (TES) approaches offer more reliable neuronal control by allowing higher intensities with tolerable side-effect profiles. This precise temporal steerability combined with the non- or minimally invasive nature of these novel TES interventions make them promising therapeutic candidates for functional disorders of the brain. Here we review the key experimental findings and theoretical background concerning various pathological aspects of neuronal network activity leading to the generation of epileptic seizures. The conceptual and practical state of the art of temporally targeted brain stimulation is discussed focusing on the prevention and early termination of epileptic seizures. |
| first_indexed | 2024-12-14T07:35:35Z |
| format | Article |
| id | doaj.art-a5a8c128832749248e2660175e67262d |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-14T07:35:35Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-a5a8c128832749248e2660175e67262d2022-12-21T23:11:13ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102021-12-011510.3389/fncir.2021.784085784085Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and BeyondTamás Földi0Tamás Földi1Tamás Földi2Tamás Földi3Magor L. Lőrincz4Magor L. Lőrincz5Magor L. Lőrincz6Magor L. Lőrincz7Antal Berényi8Antal Berényi9Antal Berényi10Antal Berényi11MTA-SZTE “Momentum” Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryNeurocybernetics Excellence Center, University of Szeged, Szeged, HungaryHCEMM-USZ Magnetotherapeutics Research Group, University of Szeged, Szeged, HungaryChild and Adolescent Psychiatry, Department of the Child Health Center, University of Szeged, Szeged, HungaryMTA-SZTE “Momentum” Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryNeurocybernetics Excellence Center, University of Szeged, Szeged, HungaryDepartment of Physiology, Anatomy and Neuroscience, Faculty of Sciences University of Szeged, Szeged, HungaryNeuroscience Division, Cardiff University, Cardiff, United KingdomMTA-SZTE “Momentum” Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryNeurocybernetics Excellence Center, University of Szeged, Szeged, HungaryHCEMM-USZ Magnetotherapeutics Research Group, University of Szeged, Szeged, HungaryNeuroscience Institute, New York University, New York, NY, United StatesSelf-organized neuronal oscillations rely on precisely orchestrated ensemble activity in reverberating neuronal networks. Chronic, non-malignant disorders of the brain are often coupled to pathological neuronal activity patterns. In addition to the characteristic behavioral symptoms, these disturbances are giving rise to both transient and persistent changes of various brain rhythms. Increasing evidence support the causal role of these “oscillopathies” in the phenotypic emergence of the disease symptoms, identifying neuronal network oscillations as potential therapeutic targets. While the kinetics of pharmacological therapy is not suitable to compensate the disease related fine-scale disturbances of network oscillations, external biophysical modalities (e.g., electrical stimulation) can alter spike timing in a temporally precise manner. These perturbations can warp rhythmic oscillatory patterns via resonance or entrainment. Properly timed phasic stimuli can even switch between the stable states of networks acting as multistable oscillators, substantially changing the emergent oscillatory patterns. Novel transcranial electric stimulation (TES) approaches offer more reliable neuronal control by allowing higher intensities with tolerable side-effect profiles. This precise temporal steerability combined with the non- or minimally invasive nature of these novel TES interventions make them promising therapeutic candidates for functional disorders of the brain. Here we review the key experimental findings and theoretical background concerning various pathological aspects of neuronal network activity leading to the generation of epileptic seizures. The conceptual and practical state of the art of temporally targeted brain stimulation is discussed focusing on the prevention and early termination of epileptic seizures.https://www.frontiersin.org/articles/10.3389/fncir.2021.784085/fulloscillationoscillopathybrain stimulationclosed-loopepilepsy |
| spellingShingle | Tamás Földi Tamás Földi Tamás Földi Tamás Földi Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Magor L. Lőrincz Antal Berényi Antal Berényi Antal Berényi Antal Berényi Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond Frontiers in Neural Circuits oscillation oscillopathy brain stimulation closed-loop epilepsy |
| title | Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond |
| title_full | Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond |
| title_fullStr | Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond |
| title_full_unstemmed | Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond |
| title_short | Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond |
| title_sort | temporally targeted interactions with pathologic oscillations as therapeutical targets in epilepsy and beyond |
| topic | oscillation oscillopathy brain stimulation closed-loop epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.784085/full |
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