A passage-dependent network for estimating the in vitro senescence of mesenchymal stromal/stem cells using microarray, bulk and single cell RNA sequencing

A passage-dependent network for estimating the in vitro senescence of mesenchymal stromal/stem cells using microarray, bulk and single cell RNA sequencing

Long-term in vitro culture of human mesenchymal stem cells (MSCs) leads to cell lifespan shortening and growth stagnation due to cell senescence. Here, using sequencing data generated in the public domain, we have established a specific regulatory network of “transcription factor (TF)-microRNA (miRN...

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Bibliographic Details
Main Authors: Yong Yang, Wencheng Zhang, Xicheng Wang, Jingxian Yang, Yangyang Cui, Haimeng Song, Weiping Li, Wei Li, Le Wu, Yao Du, Zhiying He, Jun Shi, Jiangnan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem cells (MSCs)
replicative senescence
extracellular matrix (ECM)
microRNAs (miRNAs)
in vitro expansion
regulatory network construction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.998666/full

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