Infrared neural stimulation in human cerebral cortex
Background: Modulation of brain circuits by electrical stimulation has led to exciting and powerful therapies for diseases such as Parkinson's. Because human brain organization is based in mesoscale (millimeter-scale) functional nodes, having a method that can selectively target such nodes coul...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X23016807 |
| _version_ | 1797832783755739136 |
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| author | Li Pan An Ping Kenneth E. Schriver Anna Wang Roe Junming Zhu Kedi Xu |
| author_facet | Li Pan An Ping Kenneth E. Schriver Anna Wang Roe Junming Zhu Kedi Xu |
| author_sort | Li Pan |
| collection | DOAJ |
| description | Background: Modulation of brain circuits by electrical stimulation has led to exciting and powerful therapies for diseases such as Parkinson's. Because human brain organization is based in mesoscale (millimeter-scale) functional nodes, having a method that can selectively target such nodes could enable more precise, functionally specific stimulation therapies. Infrared Neural Stimulation (INS) is an emerging stimulation technology that stimulates neural tissue via delivery of tiny heat pulses. In nonhuman primates, this optical method provides focal intensity-dependent stimulation of the brain without tissue damage. However, whether INS application to the human central nervous system (CNS) is similarly effective is unknown. Objective: To examine the effectiveness of INS on human cerebral cortex in intraoperative setting and to evaluate INS damage threshholds. Methods: Five epileptic subjects undergoing standard lobectomy for epilepsy consented to this study. Cortical response to INS was assessed by intrinsic signal optical imaging (OI, a method that detects changes in tissue reflectance due to neuronal activity). A custom integrated INS and OI system was developed specifically for short-duration INS and OI acquisition during surgical procedures. Single pulse trains of INS with intensities from 0.2 to 0.8 J/cm2 were delivered to the somatosensory cortex and responses were recorded via optical imaging. Following tissue resection, histological analysis was conducted to evaluate damage threshholds. Results: As assessed by OI, and similar to results in monkeys, INS induced responses in human cortex were highly focal (millimeter sized) and led to relative suppression of nearby cortical sites. Intensity dependence was observed at both stimulated and functionally connected sites. Histological analysis of INS-stimulated human cortical tissue provided damage threshold estimates. Conclusion: This is the first study demonstrating application of INS to human CNS and shows feasibility for stimulating single cortical nodes and associated sites and provided INS damage threshold estimates for cortical tissue. Our results suggest that INS is a promising tool for stimulation of functionally selective mesoscale circuits in the human brain, and may lead to advances in the future of precision medicine. |
| first_indexed | 2024-04-09T14:13:21Z |
| format | Article |
| id | doaj.art-a5ac9cf0dc714e7c90997257700d46e2 |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-04-09T14:13:21Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-a5ac9cf0dc714e7c90997257700d46e22023-05-06T04:37:17ZengElsevierBrain Stimulation1935-861X2023-03-01162418430Infrared neural stimulation in human cerebral cortexLi Pan0An Ping1Kenneth E. Schriver2Anna Wang Roe3Junming Zhu4Kedi Xu5Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaInterdisciplinary Institute of Neuroscience and Technology (ZIINT), School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Interdisciplinary Institute of Neuroscience and Technology (ZIINT), School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, China; Corresponding author. Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, China; Corresponding author. Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University, Hangzhou, China; Corresponding author. Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China.Background: Modulation of brain circuits by electrical stimulation has led to exciting and powerful therapies for diseases such as Parkinson's. Because human brain organization is based in mesoscale (millimeter-scale) functional nodes, having a method that can selectively target such nodes could enable more precise, functionally specific stimulation therapies. Infrared Neural Stimulation (INS) is an emerging stimulation technology that stimulates neural tissue via delivery of tiny heat pulses. In nonhuman primates, this optical method provides focal intensity-dependent stimulation of the brain without tissue damage. However, whether INS application to the human central nervous system (CNS) is similarly effective is unknown. Objective: To examine the effectiveness of INS on human cerebral cortex in intraoperative setting and to evaluate INS damage threshholds. Methods: Five epileptic subjects undergoing standard lobectomy for epilepsy consented to this study. Cortical response to INS was assessed by intrinsic signal optical imaging (OI, a method that detects changes in tissue reflectance due to neuronal activity). A custom integrated INS and OI system was developed specifically for short-duration INS and OI acquisition during surgical procedures. Single pulse trains of INS with intensities from 0.2 to 0.8 J/cm2 were delivered to the somatosensory cortex and responses were recorded via optical imaging. Following tissue resection, histological analysis was conducted to evaluate damage threshholds. Results: As assessed by OI, and similar to results in monkeys, INS induced responses in human cortex were highly focal (millimeter sized) and led to relative suppression of nearby cortical sites. Intensity dependence was observed at both stimulated and functionally connected sites. Histological analysis of INS-stimulated human cortical tissue provided damage threshold estimates. Conclusion: This is the first study demonstrating application of INS to human CNS and shows feasibility for stimulating single cortical nodes and associated sites and provided INS damage threshold estimates for cortical tissue. Our results suggest that INS is a promising tool for stimulation of functionally selective mesoscale circuits in the human brain, and may lead to advances in the future of precision medicine.http://www.sciencedirect.com/science/article/pii/S1935861X23016807Infrared neural stimulationOptical imagingCortical connectionsCerebral cortexThermal damage |
| spellingShingle | Li Pan An Ping Kenneth E. Schriver Anna Wang Roe Junming Zhu Kedi Xu Infrared neural stimulation in human cerebral cortex Brain Stimulation Infrared neural stimulation Optical imaging Cortical connections Cerebral cortex Thermal damage |
| title | Infrared neural stimulation in human cerebral cortex |
| title_full | Infrared neural stimulation in human cerebral cortex |
| title_fullStr | Infrared neural stimulation in human cerebral cortex |
| title_full_unstemmed | Infrared neural stimulation in human cerebral cortex |
| title_short | Infrared neural stimulation in human cerebral cortex |
| title_sort | infrared neural stimulation in human cerebral cortex |
| topic | Infrared neural stimulation Optical imaging Cortical connections Cerebral cortex Thermal damage |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X23016807 |
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