The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review
Gallbladder cancer is the most common malignancy of the biliary tract. When diagnosed in an advanced stage it has a very poor prognosis. Therefore, early diagnosis and thorough assessment of a suspicious gallbladder polyp is essential to improve survival rate. The aim of this systematic review is to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/8/1427 |
| _version_ | 1797524188673605632 |
|---|---|
| author | Georgios D. Koimtzis Christopher G. Chalklin Eliot Carrington-Windo Mark Ramsden Leandros Stefanopoulos Christoforos S. Kosmidis |
| author_facet | Georgios D. Koimtzis Christopher G. Chalklin Eliot Carrington-Windo Mark Ramsden Leandros Stefanopoulos Christoforos S. Kosmidis |
| author_sort | Georgios D. Koimtzis |
| collection | DOAJ |
| description | Gallbladder cancer is the most common malignancy of the biliary tract. When diagnosed in an advanced stage it has a very poor prognosis. Therefore, early diagnosis and thorough assessment of a suspicious gallbladder polyp is essential to improve survival rate. The aim of this systematic review is to assess the role of fine needle aspiration cytology (FNAC) in the management of gallbladder cancer. For that purpose, a systematic review was carried out in the MEDLINE, EMBASE, Cochrane, Scopus and Google Scholar databases between 1 July 2004 and 22 April 2021. Six studies with 283 patients in total were included. Pooled sensitivity and specificity of FNAC were 0.85 and 0.94, respectively, while the area under the calculated summary receiver operating characteristic (SROC curve (AUC) was 0.98. No complications were reported. Based on the high diagnostic performance of FNAC in the assessment of gallbladder masses, we suggest that every suspicious mass should be evaluated further with FNAC to facilitate the most appropriate management. |
| first_indexed | 2024-03-10T08:53:50Z |
| format | Article |
| id | doaj.art-a5ad580fe4ef442c9cb6ab5a2b6f47e8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T08:53:50Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a5ad580fe4ef442c9cb6ab5a2b6f47e82023-11-22T07:20:20ZengMDPI AGDiagnostics2075-44182021-08-01118142710.3390/diagnostics11081427The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic ReviewGeorgios D. Koimtzis0Christopher G. Chalklin1Eliot Carrington-Windo2Mark Ramsden3Leandros Stefanopoulos4Christoforos S. Kosmidis5Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UKCardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UKCardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UKCardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UKLab of Computing, Medical Informatics and Biomedical Imaging Technologies, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece3rd Surgical Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki (AUTH), 54621 Thessaloniki, GreeceGallbladder cancer is the most common malignancy of the biliary tract. When diagnosed in an advanced stage it has a very poor prognosis. Therefore, early diagnosis and thorough assessment of a suspicious gallbladder polyp is essential to improve survival rate. The aim of this systematic review is to assess the role of fine needle aspiration cytology (FNAC) in the management of gallbladder cancer. For that purpose, a systematic review was carried out in the MEDLINE, EMBASE, Cochrane, Scopus and Google Scholar databases between 1 July 2004 and 22 April 2021. Six studies with 283 patients in total were included. Pooled sensitivity and specificity of FNAC were 0.85 and 0.94, respectively, while the area under the calculated summary receiver operating characteristic (SROC curve (AUC) was 0.98. No complications were reported. Based on the high diagnostic performance of FNAC in the assessment of gallbladder masses, we suggest that every suspicious mass should be evaluated further with FNAC to facilitate the most appropriate management.https://www.mdpi.com/2075-4418/11/8/1427gallbladdercancerdiagnosisfine needle aspiration cytology |
| spellingShingle | Georgios D. Koimtzis Christopher G. Chalklin Eliot Carrington-Windo Mark Ramsden Leandros Stefanopoulos Christoforos S. Kosmidis The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review Diagnostics gallbladder cancer diagnosis fine needle aspiration cytology |
| title | The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review |
| title_full | The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review |
| title_fullStr | The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review |
| title_full_unstemmed | The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review |
| title_short | The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review |
| title_sort | role of fine needle aspiration cytology in the diagnosis of gallbladder cancer a systematic review |
| topic | gallbladder cancer diagnosis fine needle aspiration cytology |
| url | https://www.mdpi.com/2075-4418/11/8/1427 |
| work_keys_str_mv | AT georgiosdkoimtzis theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT christophergchalklin theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT eliotcarringtonwindo theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT markramsden theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT leandrosstefanopoulos theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT christoforosskosmidis theroleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT georgiosdkoimtzis roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT christophergchalklin roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT eliotcarringtonwindo roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT markramsden roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT leandrosstefanopoulos roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview AT christoforosskosmidis roleoffineneedleaspirationcytologyinthediagnosisofgallbladdercancerasystematicreview |