Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report
<p>Abstract</p> <p>Background</p> <p>The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/5/1/255 |
| _version_ | 1818021839427862528 |
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| author | Stavrinou Lampis C Boviatsis Efstathios J Themistocleous Marios S Stathis Pantelis Sakas Damianos E |
| author_facet | Stavrinou Lampis C Boviatsis Efstathios J Themistocleous Marios S Stathis Pantelis Sakas Damianos E |
| author_sort | Stavrinou Lampis C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs or abrupt discontinuation of neuroleptic or anti-parkinsonian agents. To the best of our knowledge, it has never been reported following the common practice of discontinuation of anti-parkinsonian drugs during the pre-operative preparation for deep brain stimulation surgery for Parkinson's disease.</p> <p>Case presentation</p> <p>We present the first case of neuroleptic malignant syndrome associated with discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery in a 54-year-old Caucasian man.</p> <p>Conclusion</p> <p>The characteristic neuroleptic malignant syndrome symptoms can be attributed to other, more common causes associated with deep brain stimulation treatment for Parkinson's disease, thus requiring a high index of clinical suspicion to timely establish the correct diagnosis. As more centers become eligible to perform deep brain stimulation, neurologists and neurosurgeons alike should be aware of this potentially fatal complication. Timely activation of the deep brain stimulation system may be important in accelerating the patient's recovery.</p> |
| first_indexed | 2024-04-14T08:23:29Z |
| format | Article |
| id | doaj.art-a5ae3985cc3f48c084f3221882dbdee6 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-14T08:23:29Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a5ae3985cc3f48c084f3221882dbdee62022-12-22T02:04:09ZengBMCJournal of Medical Case Reports1752-19472011-06-015125510.1186/1752-1947-5-255Malignant neuroleptic syndrome following deep brain stimulation surgery: a case reportStavrinou Lampis CBoviatsis Efstathios JThemistocleous Marios SStathis PantelisSakas Damianos E<p>Abstract</p> <p>Background</p> <p>The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs or abrupt discontinuation of neuroleptic or anti-parkinsonian agents. To the best of our knowledge, it has never been reported following the common practice of discontinuation of anti-parkinsonian drugs during the pre-operative preparation for deep brain stimulation surgery for Parkinson's disease.</p> <p>Case presentation</p> <p>We present the first case of neuroleptic malignant syndrome associated with discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery in a 54-year-old Caucasian man.</p> <p>Conclusion</p> <p>The characteristic neuroleptic malignant syndrome symptoms can be attributed to other, more common causes associated with deep brain stimulation treatment for Parkinson's disease, thus requiring a high index of clinical suspicion to timely establish the correct diagnosis. As more centers become eligible to perform deep brain stimulation, neurologists and neurosurgeons alike should be aware of this potentially fatal complication. Timely activation of the deep brain stimulation system may be important in accelerating the patient's recovery.</p>http://www.jmedicalcasereports.com/content/5/1/255 |
| spellingShingle | Stavrinou Lampis C Boviatsis Efstathios J Themistocleous Marios S Stathis Pantelis Sakas Damianos E Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report Journal of Medical Case Reports |
| title | Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report |
| title_full | Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report |
| title_fullStr | Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report |
| title_full_unstemmed | Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report |
| title_short | Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report |
| title_sort | malignant neuroleptic syndrome following deep brain stimulation surgery a case report |
| url | http://www.jmedicalcasereports.com/content/5/1/255 |
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