Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as ca...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013149 |
| _version_ | 1811334024334934016 |
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| author | Wendy Ying Di Zhao Pamela Ouyang Vinita Subramanya Dhananjay Vaidya Chiadi E. Ndumele Eliseo Guallar Kavita Sharma Sanjiv J. Shah David A. Kass Ron C. Hoogeveen Joao A. Lima Susan R. Heckbert Christopher R. deFilippi Wendy S. Post Erin D. Michos |
| author_facet | Wendy Ying Di Zhao Pamela Ouyang Vinita Subramanya Dhananjay Vaidya Chiadi E. Ndumele Eliseo Guallar Kavita Sharma Sanjiv J. Shah David A. Kass Ron C. Hoogeveen Joao A. Lima Susan R. Heckbert Christopher R. deFilippi Wendy S. Post Erin D. Michos |
| author_sort | Wendy Ying |
| collection | DOAJ |
| description | Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. Methods and Results We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). Conclusions In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population. |
| first_indexed | 2024-04-13T17:02:32Z |
| format | Article |
| id | doaj.art-a5aff1d352bb435a8308b9546b1ebf42 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T17:02:32Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-a5aff1d352bb435a8308b9546b1ebf422022-12-22T02:38:37ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-12-0182410.1161/JAHA.119.013149Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESAWendy Ying0Di Zhao1Pamela Ouyang2Vinita Subramanya3Dhananjay Vaidya4Chiadi E. Ndumele5Eliseo Guallar6Kavita Sharma7Sanjiv J. Shah8David A. Kass9Ron C. Hoogeveen10Joao A. Lima11Susan R. Heckbert12Christopher R. deFilippi13Wendy S. Post14Erin D. Michos15Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDepartment of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MDDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDepartment of Epidemiology Emory University Rollins School of Public Health Atlanta GADepartment of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MDDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDepartment of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MDDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDivision of Cardiology Department of Medicine Northwestern University Feinberg School of Medicine Chicago ILDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDivision of Atherosclerosis & Vascular Medicine Department of Medicine Baylor College of Medicine Houston TXDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDCardiovascular Health Research Unit and Department of Epidemiology University of Washington Seattle WAInova Heart and Vascular Institute Falls Church VADivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDDivision of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore MDBackground cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. Methods and Results We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). Conclusions In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population.https://www.ahajournals.org/doi/10.1161/JAHA.119.013149cardiovascular disease risk factorscGMPepidemiologyN‐terminal pro‐B type NPsex hormones |
| spellingShingle | Wendy Ying Di Zhao Pamela Ouyang Vinita Subramanya Dhananjay Vaidya Chiadi E. Ndumele Eliseo Guallar Kavita Sharma Sanjiv J. Shah David A. Kass Ron C. Hoogeveen Joao A. Lima Susan R. Heckbert Christopher R. deFilippi Wendy S. Post Erin D. Michos Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular disease risk factors cGMP epidemiology N‐terminal pro‐B type NP sex hormones |
| title | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
| title_full | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
| title_fullStr | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
| title_full_unstemmed | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
| title_short | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
| title_sort | associations between the cyclic guanosine monophosphate pathway and cardiovascular risk factors mesa |
| topic | cardiovascular disease risk factors cGMP epidemiology N‐terminal pro‐B type NP sex hormones |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013149 |
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