Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study
Abstract Background Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This stu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-03-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-021-08011-3 |
| _version_ | 1818676363923554304 |
|---|---|
| author | Akira Sato Keisuke Matsubayashi Toshitaka Morishima Kayo Nakata Koji Kawakami Isao Miyashiro |
| author_facet | Akira Sato Keisuke Matsubayashi Toshitaka Morishima Kayo Nakata Koji Kawakami Isao Miyashiro |
| author_sort | Akira Sato |
| collection | DOAJ |
| description | Abstract Background Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and temporal trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, cervical, and corpus uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Temporal trends were evaluated using the Cochran-Armitage trend test. Results Among 275,720 newly diagnosed cancer patients, 21,784 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, breast, and cervical cancer. Conclusions The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options. |
| first_indexed | 2024-12-17T08:42:18Z |
| format | Article |
| id | doaj.art-a5b06860520a4b3d905a83d79c1fcce3 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-17T08:42:18Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a5b06860520a4b3d905a83d79c1fcce32022-12-21T21:56:17ZengBMCBMC Cancer1471-24072021-03-0121111410.1186/s12885-021-08011-3Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based studyAkira Sato0Keisuke Matsubayashi1Toshitaka Morishima2Kayo Nakata3Koji Kawakami4Isao Miyashiro5Department of Cancer Strategy, Cancer Control Center, Osaka International Cancer InstituteDepartment of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto UniversityDepartment of Cancer Strategy, Cancer Control Center, Osaka International Cancer InstituteDepartment of Cancer Strategy, Cancer Control Center, Osaka International Cancer InstituteDepartment of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto UniversityDepartment of Cancer Strategy, Cancer Control Center, Osaka International Cancer InstituteAbstract Background Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and temporal trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, cervical, and corpus uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Temporal trends were evaluated using the Cochran-Armitage trend test. Results Among 275,720 newly diagnosed cancer patients, 21,784 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, breast, and cervical cancer. Conclusions The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options.https://doi.org/10.1186/s12885-021-08011-3Prior cancerCancer survivorsCancer registryPrevalenceSecond cancer |
| spellingShingle | Akira Sato Keisuke Matsubayashi Toshitaka Morishima Kayo Nakata Koji Kawakami Isao Miyashiro Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study BMC Cancer Prior cancer Cancer survivors Cancer registry Prevalence Second cancer |
| title | Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study |
| title_full | Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study |
| title_fullStr | Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study |
| title_full_unstemmed | Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study |
| title_short | Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study |
| title_sort | increasing trends in the prevalence of prior cancer in newly diagnosed lung stomach colorectal breast cervical and corpus uterine cancer patients a population based study |
| topic | Prior cancer Cancer survivors Cancer registry Prevalence Second cancer |
| url | https://doi.org/10.1186/s12885-021-08011-3 |
| work_keys_str_mv | AT akirasato increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy AT keisukematsubayashi increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy AT toshitakamorishima increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy AT kayonakata increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy AT kojikawakami increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy AT isaomiyashiro increasingtrendsintheprevalenceofpriorcancerinnewlydiagnosedlungstomachcolorectalbreastcervicalandcorpusuterinecancerpatientsapopulationbasedstudy |