Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?

Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain. AMPA PAMs have been shown to facilitate long-term potentiation, strengthen communication between v...

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Bibliographic Details
Main Authors: Lucas R. Watterson, M. Foster Olive
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Pharmaceuticals
Subjects:
AMPA PAMs
positive allosteric modulators
extinction
addiction
Online Access:http://www.mdpi.com/1424-8247/7/1/29

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