IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01618/full |
| _version_ | 1818550562545729536 |
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| author | Yvette Wooff Yvette Wooff Si Ming Man Riemke Aggio-Bruce Riccardo Natoli Riccardo Natoli Nilisha Fernando |
| author_facet | Yvette Wooff Yvette Wooff Si Ming Man Riemke Aggio-Bruce Riccardo Natoli Riccardo Natoli Nilisha Fernando |
| author_sort | Yvette Wooff |
| collection | DOAJ |
| description | Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In particular, the interleukin 1 (IL-1) family consisting of both pro- and anti-inflammatory cytokines has been shown to be pivotal in the mediation of innate immunity and contribute directly to a number of retinal degenerations, including Age-Related Macular Degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, glaucoma, and retinopathy of prematurity (ROP). In this review, we will discuss the role of IL-1 family members and inflammasome signaling in retinal degenerative diseases, piecing together their contribution to retinal disease pathology, and identifying areas of research expansion required to further elucidate their function in the retina. |
| first_indexed | 2024-12-12T08:48:07Z |
| format | Article |
| id | doaj.art-a5b65a103ba949bab3fb62c60fc9e574 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T08:48:07Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a5b65a103ba949bab3fb62c60fc9e5742022-12-22T00:30:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01618462812IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesYvette Wooff0Yvette Wooff1Si Ming Man2Riemke Aggio-Bruce3Riccardo Natoli4Riccardo Natoli5Nilisha Fernando6The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaANU Medical School, The Australian National University, Canberra, ACT, AustraliaThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaANU Medical School, The Australian National University, Canberra, ACT, AustraliaThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaInflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In particular, the interleukin 1 (IL-1) family consisting of both pro- and anti-inflammatory cytokines has been shown to be pivotal in the mediation of innate immunity and contribute directly to a number of retinal degenerations, including Age-Related Macular Degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, glaucoma, and retinopathy of prematurity (ROP). In this review, we will discuss the role of IL-1 family members and inflammasome signaling in retinal degenerative diseases, piecing together their contribution to retinal disease pathology, and identifying areas of research expansion required to further elucidate their function in the retina.https://www.frontiersin.org/article/10.3389/fimmu.2019.01618/fullretinal degenerationIL-1 (interleukin-1)age-related macular degeneration (AMD)inflammationcytokineinflammasome |
| spellingShingle | Yvette Wooff Yvette Wooff Si Ming Man Riemke Aggio-Bruce Riccardo Natoli Riccardo Natoli Nilisha Fernando IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases Frontiers in Immunology retinal degeneration IL-1 (interleukin-1) age-related macular degeneration (AMD) inflammation cytokine inflammasome |
| title | IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases |
| title_full | IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases |
| title_fullStr | IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases |
| title_full_unstemmed | IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases |
| title_short | IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases |
| title_sort | il 1 family members mediate cell death inflammation and angiogenesis in retinal degenerative diseases |
| topic | retinal degeneration IL-1 (interleukin-1) age-related macular degeneration (AMD) inflammation cytokine inflammasome |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01618/full |
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