Zika virus: An emerging challenge for obstetrics and gynecology
Microcephaly is a rare birth defect, however, the re-emerging mosquito and sexual transmitted flavivirus, Zika virus (ZIKV), had changed the situation and caused an urgent challenge for the obstetrics and gynecology. This review will brief summarize the epidemiology and virology of ZIKV. And compare...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455917301912 |
| _version_ | 1811261199349710848 |
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| author | Jhe-Jhih Lin Ting-Yu Chin Chih-Ping Chen Hong-Lin Chan Tzong-Yuan Wu |
| author_facet | Jhe-Jhih Lin Ting-Yu Chin Chih-Ping Chen Hong-Lin Chan Tzong-Yuan Wu |
| author_sort | Jhe-Jhih Lin |
| collection | DOAJ |
| description | Microcephaly is a rare birth defect, however, the re-emerging mosquito and sexual transmitted flavivirus, Zika virus (ZIKV), had changed the situation and caused an urgent challenge for the obstetrics and gynecology. This review will brief summarize the epidemiology and virology of ZIKV. And compared the animal models that had developed for the ZIKV infections. These animal models will be benefit for the development of vaccines and anti-ZIKV drugs. Furthermore, the genes that are involved in the causation of microcephaly were also summarized. Finally, the Wnt signal is critical for the brain development as well as innate immune response. Based on previous literatures, we proposed that ZIKV-induced microcephaly might result from the influence of Wnt/β-catenin signaling pathway through the regulation of miRNA-34. |
| first_indexed | 2024-04-12T18:59:53Z |
| format | Article |
| id | doaj.art-a5b6b34ddeb646ebbfd8f31d7d9107d7 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-04-12T18:59:53Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-a5b6b34ddeb646ebbfd8f31d7d9107d72022-12-22T03:20:12ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592017-10-0156558559210.1016/j.tjog.2017.08.003Zika virus: An emerging challenge for obstetrics and gynecologyJhe-Jhih Lin0Ting-Yu Chin1Chih-Ping Chen2Hong-Lin Chan3Tzong-Yuan Wu4Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, TaiwanDepartment of Bioscience Technology, Chung Yuan Christian University, Chungli, TaiwanDepartment of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, TaiwanInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, TaiwanDepartment of Bioscience Technology, Chung Yuan Christian University, Chungli, TaiwanMicrocephaly is a rare birth defect, however, the re-emerging mosquito and sexual transmitted flavivirus, Zika virus (ZIKV), had changed the situation and caused an urgent challenge for the obstetrics and gynecology. This review will brief summarize the epidemiology and virology of ZIKV. And compared the animal models that had developed for the ZIKV infections. These animal models will be benefit for the development of vaccines and anti-ZIKV drugs. Furthermore, the genes that are involved in the causation of microcephaly were also summarized. Finally, the Wnt signal is critical for the brain development as well as innate immune response. Based on previous literatures, we proposed that ZIKV-induced microcephaly might result from the influence of Wnt/β-catenin signaling pathway through the regulation of miRNA-34.http://www.sciencedirect.com/science/article/pii/S1028455917301912FlavivirusMicrocephalymiRNA-34Wnt/β-catenin signaling pathwayZika virus |
| spellingShingle | Jhe-Jhih Lin Ting-Yu Chin Chih-Ping Chen Hong-Lin Chan Tzong-Yuan Wu Zika virus: An emerging challenge for obstetrics and gynecology Taiwanese Journal of Obstetrics & Gynecology Flavivirus Microcephaly miRNA-34 Wnt/β-catenin signaling pathway Zika virus |
| title | Zika virus: An emerging challenge for obstetrics and gynecology |
| title_full | Zika virus: An emerging challenge for obstetrics and gynecology |
| title_fullStr | Zika virus: An emerging challenge for obstetrics and gynecology |
| title_full_unstemmed | Zika virus: An emerging challenge for obstetrics and gynecology |
| title_short | Zika virus: An emerging challenge for obstetrics and gynecology |
| title_sort | zika virus an emerging challenge for obstetrics and gynecology |
| topic | Flavivirus Microcephaly miRNA-34 Wnt/β-catenin signaling pathway Zika virus |
| url | http://www.sciencedirect.com/science/article/pii/S1028455917301912 |
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