Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12
Psychrophilic organisms possess several adaptive strategies which allow them to sustain life at low temperatures between −20 to 20 °C. Studies on Antarctic psychrophiles are interesting due to the multiple stressors that exist on the permanently cold continent. These organisms produce, among other p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/7/528 |
| _version_ | 1827688380706586624 |
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| author | Nur Athirah Yusof Noor Haza Fazlin Hashim Izwan Bharudin |
| author_facet | Nur Athirah Yusof Noor Haza Fazlin Hashim Izwan Bharudin |
| author_sort | Nur Athirah Yusof |
| collection | DOAJ |
| description | Psychrophilic organisms possess several adaptive strategies which allow them to sustain life at low temperatures between −20 to 20 °C. Studies on Antarctic psychrophiles are interesting due to the multiple stressors that exist on the permanently cold continent. These organisms produce, among other peculiarities, cold-active enzymes which not only have tremendous biotechnological potential but are valuable models for fundamental research into protein structure and function. Recent innovations in omics technologies such as genomics, transcriptomics, proteomics and metabolomics have contributed a remarkable perspective of the molecular basis underpinning the mechanisms of cold adaptation. This review critically discusses similar and different strategies of cold adaptation in the obligate psychrophilic yeast, <i>Glaciozyma antarctica</i> PI12 at the molecular (genome structure, proteins and enzymes, gene expression) and physiological (antifreeze proteins, membrane fluidity, stress-related proteins) levels. Our extensive studies on <i>G. antarctica</i> have revealed significant insights towards the innate capacity of- and the adaptation strategies employed by this psychrophilic yeast for life in the persistent cold. Furthermore, several cold-active enzymes and proteins with biotechnological potential are also discussed. |
| first_indexed | 2024-03-10T09:54:59Z |
| format | Article |
| id | doaj.art-a5b7cb84bf684185b1c87f50d671bfe9 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T09:54:59Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-a5b7cb84bf684185b1c87f50d671bfe92023-11-22T02:24:52ZengMDPI AGJournal of Fungi2309-608X2021-06-017752810.3390/jof7070528Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12Nur Athirah Yusof0Noor Haza Fazlin Hashim1Izwan Bharudin2Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu 88400, Sabah, MalaysiaWater Quality Laboratory, National Water Research Institute Malaysia (NAHRIM), Ministry of Environment and Water, Jalan Putra Permai, Seri Kembangan 43300, Selangor, MalaysiaDepartment of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, MalaysiaPsychrophilic organisms possess several adaptive strategies which allow them to sustain life at low temperatures between −20 to 20 °C. Studies on Antarctic psychrophiles are interesting due to the multiple stressors that exist on the permanently cold continent. These organisms produce, among other peculiarities, cold-active enzymes which not only have tremendous biotechnological potential but are valuable models for fundamental research into protein structure and function. Recent innovations in omics technologies such as genomics, transcriptomics, proteomics and metabolomics have contributed a remarkable perspective of the molecular basis underpinning the mechanisms of cold adaptation. This review critically discusses similar and different strategies of cold adaptation in the obligate psychrophilic yeast, <i>Glaciozyma antarctica</i> PI12 at the molecular (genome structure, proteins and enzymes, gene expression) and physiological (antifreeze proteins, membrane fluidity, stress-related proteins) levels. Our extensive studies on <i>G. antarctica</i> have revealed significant insights towards the innate capacity of- and the adaptation strategies employed by this psychrophilic yeast for life in the persistent cold. Furthermore, several cold-active enzymes and proteins with biotechnological potential are also discussed.https://www.mdpi.com/2309-608X/7/7/528Antarcticaantifreeze proteincold-active proteinscold adaptationmembrane fluiditypsychrophilic yeast |
| spellingShingle | Nur Athirah Yusof Noor Haza Fazlin Hashim Izwan Bharudin Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 Journal of Fungi Antarctica antifreeze protein cold-active proteins cold adaptation membrane fluidity psychrophilic yeast |
| title | Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 |
| title_full | Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 |
| title_fullStr | Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 |
| title_full_unstemmed | Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 |
| title_short | Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, <i>Glaciozyma antarctica</i> PI12 |
| title_sort | cold adaptation strategies and the potential of psychrophilic enzymes from the antarctic yeast i glaciozyma antarctica i pi12 |
| topic | Antarctica antifreeze protein cold-active proteins cold adaptation membrane fluidity psychrophilic yeast |
| url | https://www.mdpi.com/2309-608X/7/7/528 |
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