A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted.
Calculating the cost per disability-adjusted life years (DALYs) averted associated with interventions is an increasing popular means of assessing the cost-effectiveness of strategies to improve population health. However, there has been no systematic attempt to characterize the literature and its ev...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5179084?pdf=render |
| _version_ | 1828808922122682368 |
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| author | Peter J Neumann Teja Thorat Yue Zhong Jordan Anderson Megan Farquhar Mark Salem Eileen Sandberg Cayla J Saret Colby Wilkinson Joshua T Cohen |
| author_facet | Peter J Neumann Teja Thorat Yue Zhong Jordan Anderson Megan Farquhar Mark Salem Eileen Sandberg Cayla J Saret Colby Wilkinson Joshua T Cohen |
| author_sort | Peter J Neumann |
| collection | DOAJ |
| description | Calculating the cost per disability-adjusted life years (DALYs) averted associated with interventions is an increasing popular means of assessing the cost-effectiveness of strategies to improve population health. However, there has been no systematic attempt to characterize the literature and its evolution.We conducted a systematic review of cost-effectiveness studies reporting cost-per-DALY averted from 2000 through 2015. We developed the Global Health Cost-Effectiveness Analysis (GHCEA) Registry, a repository of English-language cost-per-DALY averted studies indexed in PubMed. To identify candidate studies, we searched PubMed for articles with titles or abstracts containing the phrases "disability-adjusted" or "DALY". Two reviewers with training in health economics independently reviewed each article selected in our abstract review, gathering information using a standardized data collection form. We summarized descriptive characteristics on study methodology: e.g., intervention type, country of study, study funder, study perspective, along with methodological and reporting practices over two time periods: 2000-2009 and 2010-2015. We analyzed the types of costs included in analyses, the study quality on a scale from 1 (low) to 7 (high), and examined the correlation between diseases researched and the burden of disease in different world regions.We identified 479 cost-per-DALY averted studies published from 2000 through 2015. Studies from Sub-Saharan Africa comprised the largest portion of published studies. The disease areas most commonly studied were communicable, maternal, neonatal, and nutritional disorders (67%), followed by non-communicable diseases (28%). A high proportion of studies evaluated primary prevention strategies (59%). Pharmaceutical interventions were commonly assessed (32%) followed by immunizations (28%). Adherence to good practices for conducting and reporting cost-effectiveness analysis varied considerably. Studies mainly included formal healthcare sector costs. A large number of the studies in Sub-Saharan Africa addressed high-burden conditions such as HIV/AIDS, tuberculosis, neglected tropical diseases and malaria, and diarrhea, lower respiratory infections, meningitis, and other common infectious diseases.The Global Health Cost-Effectiveness Analysis Registry reveals a growing and diverse field of cost-per-DALY averted studies. However, study methods and reporting practices have varied substantially. |
| first_indexed | 2024-12-12T08:48:08Z |
| format | Article |
| id | doaj.art-a5b826284e4a4ae7ba9d0c951d698784 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T08:48:08Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-a5b826284e4a4ae7ba9d0c951d6987842022-12-22T00:30:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016851210.1371/journal.pone.0168512A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted.Peter J NeumannTeja ThoratYue ZhongJordan AndersonMegan FarquharMark SalemEileen SandbergCayla J SaretColby WilkinsonJoshua T CohenCalculating the cost per disability-adjusted life years (DALYs) averted associated with interventions is an increasing popular means of assessing the cost-effectiveness of strategies to improve population health. However, there has been no systematic attempt to characterize the literature and its evolution.We conducted a systematic review of cost-effectiveness studies reporting cost-per-DALY averted from 2000 through 2015. We developed the Global Health Cost-Effectiveness Analysis (GHCEA) Registry, a repository of English-language cost-per-DALY averted studies indexed in PubMed. To identify candidate studies, we searched PubMed for articles with titles or abstracts containing the phrases "disability-adjusted" or "DALY". Two reviewers with training in health economics independently reviewed each article selected in our abstract review, gathering information using a standardized data collection form. We summarized descriptive characteristics on study methodology: e.g., intervention type, country of study, study funder, study perspective, along with methodological and reporting practices over two time periods: 2000-2009 and 2010-2015. We analyzed the types of costs included in analyses, the study quality on a scale from 1 (low) to 7 (high), and examined the correlation between diseases researched and the burden of disease in different world regions.We identified 479 cost-per-DALY averted studies published from 2000 through 2015. Studies from Sub-Saharan Africa comprised the largest portion of published studies. The disease areas most commonly studied were communicable, maternal, neonatal, and nutritional disorders (67%), followed by non-communicable diseases (28%). A high proportion of studies evaluated primary prevention strategies (59%). Pharmaceutical interventions were commonly assessed (32%) followed by immunizations (28%). Adherence to good practices for conducting and reporting cost-effectiveness analysis varied considerably. Studies mainly included formal healthcare sector costs. A large number of the studies in Sub-Saharan Africa addressed high-burden conditions such as HIV/AIDS, tuberculosis, neglected tropical diseases and malaria, and diarrhea, lower respiratory infections, meningitis, and other common infectious diseases.The Global Health Cost-Effectiveness Analysis Registry reveals a growing and diverse field of cost-per-DALY averted studies. However, study methods and reporting practices have varied substantially.http://europepmc.org/articles/PMC5179084?pdf=render |
| spellingShingle | Peter J Neumann Teja Thorat Yue Zhong Jordan Anderson Megan Farquhar Mark Salem Eileen Sandberg Cayla J Saret Colby Wilkinson Joshua T Cohen A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. PLoS ONE |
| title | A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. |
| title_full | A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. |
| title_fullStr | A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. |
| title_full_unstemmed | A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. |
| title_short | A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted. |
| title_sort | systematic review of cost effectiveness studies reporting cost per daly averted |
| url | http://europepmc.org/articles/PMC5179084?pdf=render |
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