Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients
Abstract Background The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG pa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03059-0 |
| _version_ | 1797778994347638784 |
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| author | Nana Takahashi Naoki Kiyota Hiroshi Kunikata Mai Yamazaki Takayuki Nishimura Yukihiro Shiga Hisae Aoyagi Miwako Shidomi Tomohiro Tsuda Toshihiko Ohtsuka Takahiro Tomida Toru Nakazawa |
| author_facet | Nana Takahashi Naoki Kiyota Hiroshi Kunikata Mai Yamazaki Takayuki Nishimura Yukihiro Shiga Hisae Aoyagi Miwako Shidomi Tomohiro Tsuda Toshihiko Ohtsuka Takahiro Tomida Toru Nakazawa |
| author_sort | Nana Takahashi |
| collection | DOAJ |
| description | Abstract Background The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG patients and healthy controls. Methods We performed cold-water provocation in 14 eyes of 14 NTG patients and 15 eyes of 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), skin blood flowmetry-derived pulse wave amplitude (PA), nailfold capillaroscopy-derived nailfold capillary diameter, and other clinical parameters were recorded at baseline and 4 and 6 min after the cold stimulus. We compared changes (as percentages) in these variables in the NTG and control subjects with a linear mixed-effects model and evaluated correlations between these changes with Spearman’s rank correlation coefficient. Results The interaction term between the NTG group (reference, control group) and the 4-min protocol step (reference, baseline) significantly affected the changes in MT, nailfold capillary diameter and PA (β = -9.51%, P = 0.017, β = -20.32%, P = 0.002; β = + 18.06%, P = 0.017, respectively). The change in MT was positively correlated with the change in nailfold capillary diameter, and negatively correlated with the change in PA (r = 0.39, P = 0.036; r = -0.40, P = 0.031, respectively). Conclusion NTG patients showed abnormal vasoconstriction in the ONH and nailfold and vasodilation in the facial skin in response to cold-water provocation. |
| first_indexed | 2024-03-12T23:25:26Z |
| format | Article |
| id | doaj.art-a5b827138f16440c99d18c87114ffe49 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-12T23:25:26Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-a5b827138f16440c99d18c87114ffe492023-07-16T11:12:42ZengBMCBMC Ophthalmology1471-24152023-07-0123111110.1186/s12886-023-03059-0Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patientsNana Takahashi0Naoki Kiyota1Hiroshi Kunikata2Mai Yamazaki3Takayuki Nishimura4Yukihiro Shiga5Hisae Aoyagi6Miwako Shidomi7Tomohiro Tsuda8Toshihiko Ohtsuka9Takahiro Tomida10Toru Nakazawa11Department of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Health Science Research Planning Division, Rohto Pharmaceutical Co., LtdDepartment of Health Science Research Planning Division, Rohto Pharmaceutical Co., LtdDepartment of Internal Medicine and Food Development Division, Rohto Pharmaceutical Co., LtdDepartment of Advanced Development, Casio Computer Co., LtdDepartment of Advanced Development, Casio Computer Co., LtdDepartment of Ophthalmology, Tohoku University Graduate School of MedicineAbstract Background The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG patients and healthy controls. Methods We performed cold-water provocation in 14 eyes of 14 NTG patients and 15 eyes of 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), skin blood flowmetry-derived pulse wave amplitude (PA), nailfold capillaroscopy-derived nailfold capillary diameter, and other clinical parameters were recorded at baseline and 4 and 6 min after the cold stimulus. We compared changes (as percentages) in these variables in the NTG and control subjects with a linear mixed-effects model and evaluated correlations between these changes with Spearman’s rank correlation coefficient. Results The interaction term between the NTG group (reference, control group) and the 4-min protocol step (reference, baseline) significantly affected the changes in MT, nailfold capillary diameter and PA (β = -9.51%, P = 0.017, β = -20.32%, P = 0.002; β = + 18.06%, P = 0.017, respectively). The change in MT was positively correlated with the change in nailfold capillary diameter, and negatively correlated with the change in PA (r = 0.39, P = 0.036; r = -0.40, P = 0.031, respectively). Conclusion NTG patients showed abnormal vasoconstriction in the ONH and nailfold and vasodilation in the facial skin in response to cold-water provocation.https://doi.org/10.1186/s12886-023-03059-0Ocular blood flowLaser speckle flowgraphyAutoregulationVasoreactivity |
| spellingShingle | Nana Takahashi Naoki Kiyota Hiroshi Kunikata Mai Yamazaki Takayuki Nishimura Yukihiro Shiga Hisae Aoyagi Miwako Shidomi Tomohiro Tsuda Toshihiko Ohtsuka Takahiro Tomida Toru Nakazawa Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients BMC Ophthalmology Ocular blood flow Laser speckle flowgraphy Autoregulation Vasoreactivity |
| title | Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients |
| title_full | Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients |
| title_fullStr | Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients |
| title_full_unstemmed | Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients |
| title_short | Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients |
| title_sort | vasoreactivity of the optic nerve head nailfold and facial skin in response to cold provocation in normal tension glaucoma patients |
| topic | Ocular blood flow Laser speckle flowgraphy Autoregulation Vasoreactivity |
| url | https://doi.org/10.1186/s12886-023-03059-0 |
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