Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis.
Hereditary transthyretin amyloidosis is an autosomal dominant form of amyloidosis caused by an abnormality in transthyretin, with various ocular manifestations. Among these, ocular amyloid angiopathy has attracted attention because of its direct link to visual impairment and its correlation with sys...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0275180 |
| _version_ | 1811226246378422272 |
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| author | Shinji Kakihara Takao Hirano Junya Kitahara Yorishige Matsuda Akira Imai Teruyoshi Miyahara Toshinori Murata |
| author_facet | Shinji Kakihara Takao Hirano Junya Kitahara Yorishige Matsuda Akira Imai Teruyoshi Miyahara Toshinori Murata |
| author_sort | Shinji Kakihara |
| collection | DOAJ |
| description | Hereditary transthyretin amyloidosis is an autosomal dominant form of amyloidosis caused by an abnormality in transthyretin, with various ocular manifestations. Among these, ocular amyloid angiopathy has attracted attention because of its direct link to visual impairment and its correlation with systemic severity. We hypothesized that optical coherence tomography angiographic parameters would be useful biomarkers of amyloidosis systemic severity and investigated their correlation with the systemic severity score. The primary outcome was the correlation between the systemic severity score and choriocapillaris flow deficit percentage. Secondary outcomes were the correlations between the systemic severity score and retinal optical coherence tomography angiographic parameters, including foveal avascular zone size and circularity and superficial/deep/total retinal perfusion and vessel densities. The choroidal and retinal vasculature was quantified in 36 eyes from 36 patients (age, 51.8±12.1 years; disease duration, 13.4±6.2 years). Ten eyes had a history of vitrectomy for vitreous opacity. Choriocapillaris flow deficit percentage was not significantly correlated with the systemic severity score (Spearman's rank correlation: r = 2.96×10-2, p = 0.863). Similarly, foveal avascular zone size and circularity, and superficial/deep/total retinal perfusion and vessel densities were not significantly correlated with the systemic severity score. These results may indicate that optical coherence tomography angiographic parameters are not sufficient to predict amyloidosis severity. |
| first_indexed | 2024-04-12T09:21:48Z |
| format | Article |
| id | doaj.art-a5b84aa7891c4bddbbb0d2701ca365e6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T09:21:48Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a5b84aa7891c4bddbbb0d2701ca365e62022-12-22T03:38:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027518010.1371/journal.pone.0275180Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis.Shinji KakiharaTakao HiranoJunya KitaharaYorishige MatsudaAkira ImaiTeruyoshi MiyaharaToshinori MurataHereditary transthyretin amyloidosis is an autosomal dominant form of amyloidosis caused by an abnormality in transthyretin, with various ocular manifestations. Among these, ocular amyloid angiopathy has attracted attention because of its direct link to visual impairment and its correlation with systemic severity. We hypothesized that optical coherence tomography angiographic parameters would be useful biomarkers of amyloidosis systemic severity and investigated their correlation with the systemic severity score. The primary outcome was the correlation between the systemic severity score and choriocapillaris flow deficit percentage. Secondary outcomes were the correlations between the systemic severity score and retinal optical coherence tomography angiographic parameters, including foveal avascular zone size and circularity and superficial/deep/total retinal perfusion and vessel densities. The choroidal and retinal vasculature was quantified in 36 eyes from 36 patients (age, 51.8±12.1 years; disease duration, 13.4±6.2 years). Ten eyes had a history of vitrectomy for vitreous opacity. Choriocapillaris flow deficit percentage was not significantly correlated with the systemic severity score (Spearman's rank correlation: r = 2.96×10-2, p = 0.863). Similarly, foveal avascular zone size and circularity, and superficial/deep/total retinal perfusion and vessel densities were not significantly correlated with the systemic severity score. These results may indicate that optical coherence tomography angiographic parameters are not sufficient to predict amyloidosis severity.https://doi.org/10.1371/journal.pone.0275180 |
| spellingShingle | Shinji Kakihara Takao Hirano Junya Kitahara Yorishige Matsuda Akira Imai Teruyoshi Miyahara Toshinori Murata Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. PLoS ONE |
| title | Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. |
| title_full | Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. |
| title_fullStr | Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. |
| title_full_unstemmed | Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. |
| title_short | Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis. |
| title_sort | application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis |
| url | https://doi.org/10.1371/journal.pone.0275180 |
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