Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/17/2162 |
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| author | Farina Mohamad Yusoff Yukihito Higashi |
| author_facet | Farina Mohamad Yusoff Yukihito Higashi |
| author_sort | Farina Mohamad Yusoff |
| collection | DOAJ |
| description | Mesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review. |
| first_indexed | 2024-03-10T23:25:59Z |
| format | Article |
| id | doaj.art-a5b91ed92d7b486ea2303655ee9339b6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T23:25:59Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a5b91ed92d7b486ea2303655ee9339b62023-11-19T07:58:07ZengMDPI AGCells2073-44092023-08-011217216210.3390/cells12172162Mesenchymal Stem/Stromal Cells for Therapeutic AngiogenesisFarina Mohamad Yusoff0Yukihito Higashi1Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanMesenchymal stem/stromal cells (MSCs) are known to possess medicinal properties to facilitate vascular regeneration. Recent advances in the understanding of the utilities of MSCs in physiological/pathological tissue repair and technologies in isolation, expansion, and enhancement strategies have led to the use of MSCs for vascular disease-related treatments. Various conditions, including chronic arterial occlusive disease, diabetic ulcers, and chronic wounds, cause significant morbidity in patients. Therapeutic angiogenesis by cell therapy has led to the possibilities of treatment options in promoting angiogenesis, treating chronic wounds, and improving amputation-free survival. Current perspectives on the options for the use of MSCs for therapeutic angiogenesis in vascular research and in medicine, either as a monotherapy or in combination with conventional interventions, for treating patients with peripheral artery diseases are discussed in this review.https://www.mdpi.com/2073-4409/12/17/2162critical limb ischemiamesenchymal stem/stromal cellstherapeutic angiogenesis |
| spellingShingle | Farina Mohamad Yusoff Yukihito Higashi Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis Cells critical limb ischemia mesenchymal stem/stromal cells therapeutic angiogenesis |
| title | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
| title_full | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
| title_fullStr | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
| title_full_unstemmed | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
| title_short | Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis |
| title_sort | mesenchymal stem stromal cells for therapeutic angiogenesis |
| topic | critical limb ischemia mesenchymal stem/stromal cells therapeutic angiogenesis |
| url | https://www.mdpi.com/2073-4409/12/17/2162 |
| work_keys_str_mv | AT farinamohamadyusoff mesenchymalstemstromalcellsfortherapeuticangiogenesis AT yukihitohigashi mesenchymalstemstromalcellsfortherapeuticangiogenesis |