SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation

SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation

The initiation of Okazaki fragment synthesis during cellular DNA replication is a crucial step for lagging strand synthesis, which is carried out by the primase function of DNA polymerase α‐primase (Pol‐prim). Since cellular replication protein A (RPA) prevents primase from starting RNA synthesis on...

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Bibliographic Details
Main Authors: Nichodemus O. Onwubiko, Felicia Scheffel, Ingrid Tessmer, Heinz Peter Nasheuer
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:FEBS Open Bio
Subjects:
DNA polymerase α‐primase (Pol α)
eukaryotic DNA replication
initiation reaction
Okazaki fragment synthesis
replication protein A (RPA)
SV40 large T antigen
Online Access:https://doi.org/10.1002/2211-5463.13373

Internet

https://doi.org/10.1002/2211-5463.13373

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