2543 High concentrations of CXCL12 decrease pancreatic adenocarcinoma growth

OBJECTIVES/SPECIFIC AIMS: We hypothesized that CXCL12, as a biased dimer variant or secreted at dimer-dominant concentrations, would influence PDAC growth and progression. METHODS/STUDY POPULATION: PDAC cells were genetically manipulated to express dimer-promoting levels of CXCL12. These cells were...

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Bibliographic Details
Main Authors: Emily Vonderhaar, Michael Dwinell, Ishan R. Roy, Donna M. McAllister, Michael B. Dwinell
Format: Article
Language:English
Published: Cambridge University Press 2018-06-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866118000791/type/journal_article