Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications
The development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4292 |
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| author | Ana C. S. Veríssimo Mário Pacheco Artur M. S. Silva Diana C. G. A. Pinto |
| author_facet | Ana C. S. Veríssimo Mário Pacheco Artur M. S. Silva Diana C. G. A. Pinto |
| author_sort | Ana C. S. Veríssimo |
| collection | DOAJ |
| description | The development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has proved to be a huge source of bioactive compounds, making the discovery and study of these compounds a growing area. In the last few years, several compounds of marine origin, which include algae, corals, and sea urchins, have been isolated, studied, and demonstrated to possess anticancer properties. These compounds, mainly from securamines and sterols families, have been tested for cytotoxic/antiproliferative activity in different cell lines. Bioactive compounds isolated from marine organisms in the past 5 years that have shown anticancer activity, emphasizing the ones that showed the highest cytotoxic activity, such as securamines H and I, cholest-3β,5α,6β-triol, (<i>E</i>)-24-methylcholest-22-ene-3β,5α,6β-triol, 24-methylenecholesta-3β,5α,6β-triol, and 24-methylcholesta-3β,5α,6β-triol, will be discussed in this review. These studies reveal the possibility of new compounds of marine origin being used as new therapeutic agents or as a source of inspiration to develop new therapeutic agents. |
| first_indexed | 2024-03-10T09:30:45Z |
| format | Article |
| id | doaj.art-a5c0541bb75848af86d2b545abdf8a3e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:30:45Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a5c0541bb75848af86d2b545abdf8a3e2023-11-22T04:31:33ZengMDPI AGMolecules1420-30492021-07-012614429210.3390/molecules26144292Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer ApplicationsAna C. S. Veríssimo0Mário Pacheco1Artur M. S. Silva2Diana C. G. A. Pinto3LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, PortugalLAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalLAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalThe development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has proved to be a huge source of bioactive compounds, making the discovery and study of these compounds a growing area. In the last few years, several compounds of marine origin, which include algae, corals, and sea urchins, have been isolated, studied, and demonstrated to possess anticancer properties. These compounds, mainly from securamines and sterols families, have been tested for cytotoxic/antiproliferative activity in different cell lines. Bioactive compounds isolated from marine organisms in the past 5 years that have shown anticancer activity, emphasizing the ones that showed the highest cytotoxic activity, such as securamines H and I, cholest-3β,5α,6β-triol, (<i>E</i>)-24-methylcholest-22-ene-3β,5α,6β-triol, 24-methylenecholesta-3β,5α,6β-triol, and 24-methylcholesta-3β,5α,6β-triol, will be discussed in this review. These studies reveal the possibility of new compounds of marine origin being used as new therapeutic agents or as a source of inspiration to develop new therapeutic agents.https://www.mdpi.com/1420-3049/26/14/4292secondary metabolitesmarine organismssecuraminessterolsanticancercytotoxic activity |
| spellingShingle | Ana C. S. Veríssimo Mário Pacheco Artur M. S. Silva Diana C. G. A. Pinto Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications Molecules secondary metabolites marine organisms securamines sterols anticancer cytotoxic activity |
| title | Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications |
| title_full | Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications |
| title_fullStr | Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications |
| title_full_unstemmed | Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications |
| title_short | Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications |
| title_sort | secondary metabolites from marine sources with potential use as leads for anticancer applications |
| topic | secondary metabolites marine organisms securamines sterols anticancer cytotoxic activity |
| url | https://www.mdpi.com/1420-3049/26/14/4292 |
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