Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling

Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling

Abstract Background Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to ascertain whether PDE-3 inhibition can elicit migraine-lik...

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Bibliographic Details
Main Authors: Haidar M. Al-Khazali, Rune H. Christensen, Basit Ali Chaudhry, Anna G. Melchior, Messoud Ashina, Rami Burstein, Håkan Ashina
Format: Article
Language:English
Published: BMC 2024-04-01
Series:The Journal of Headache and Pain
Subjects:
Headache
Pain
Nociception
cAMP-Dependent signaling
Online Access:https://doi.org/10.1186/s10194-024-01762-x

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